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Title: | Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis | Authors: | Li, Kan Yan Chloe Dejea, Hector De Winne, Koen Bonnin, Anne D'ONOFRIO, Valentino COX, Janneke Garcia-Canadilla, Patricia Lammens, Martin Cook, Andrew C. Bijnens, Bart Dendooven, Amelie |
Issue Date: | 2023 | Publisher: | SPRINGER | Source: | HISTOCHEMISTRY AND CELL BIOLOGY, 160 (5) , p. 377 -389 | Abstract: | X-ray phase contrast imaging (X-PCI) is a powerful technique for high-resolution, three-dimensional imaging of soft tissue samples in a non-destructive manner. In this technical report, we assess the quality of standard histopathological techniques performed on formalin-fixed, paraffin-embedded (FFPE) human tissue samples that have been irradiated with different doses of X-rays in the context of an X-PCI experiment. The data from this study demonstrate that routine histochemical and immunohistochemical staining quality as well as DNA and RNA analyses are not affected by previous X-PCI on human FFPE samples. From these data we conclude it is feasible and acceptable to perform X-PCI on FFPE human biopsies. | Notes: | Dendooven, A (corresponding author), Antwerp Univ Hosp, Univ Antwerp, Dept Pathol, Antwerp, Belgium.; Dendooven, A (corresponding author), Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. Amelie.dendooven@uzgent.be |
Keywords: | X-ray phase contrast imaging;Pathology;Needle biopsies | Document URI: | http://hdl.handle.net/1942/41685 | ISSN: | 0948-6143 | e-ISSN: | 1432-119X | DOI: | 10.1007/s00418-023-02220-6 | ISI #: | 001040154200001 | Rights: | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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