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http://hdl.handle.net/1942/41911
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DC Field | Value | Language |
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dc.contributor.author | Denayer, Sarah | - |
dc.contributor.author | Dufrasne, Francois E. | - |
dc.contributor.author | Monsieurs, Bert | - |
dc.contributor.author | Van Eycken, Reinout | - |
dc.contributor.author | Houben , Sarah | - |
dc.contributor.author | Seyler, Lucie | - |
dc.contributor.author | Demuyser, Thomas | - |
dc.contributor.author | Van Nedervelde, Els | - |
dc.contributor.author | Bourgeois, Marc | - |
dc.contributor.author | Delaere, Benedicte | - |
dc.contributor.author | MAGERMAN, Koen | - |
dc.contributor.author | Jouck, Door | - |
dc.contributor.author | Lissoir, Benedicte | - |
dc.contributor.author | Sion, Catherine | - |
dc.contributor.author | Reynders , Marijke | - |
dc.contributor.author | Petit, Evelyn | - |
dc.contributor.author | Dauby, Nicolas | - |
dc.contributor.author | Hainaut, Marc | - |
dc.contributor.author | Laenen , Lies | - |
dc.contributor.author | Maes, Piet | - |
dc.contributor.author | Baele, Guy | - |
dc.contributor.author | Dellicour, Simon | - |
dc.contributor.author | Cuypers, Lize | - |
dc.contributor.author | Andre, Emmanuel | - |
dc.contributor.author | Couvreur, Simon | - |
dc.contributor.author | Brondeel, Ruben | - |
dc.contributor.author | Barbezange, Cyril | - |
dc.contributor.author | Bossuyt, Nathalie | - |
dc.contributor.author | Van Gucht, Steven | - |
dc.date.accessioned | 2023-12-04T08:18:07Z | - |
dc.date.available | 2023-12-04T08:18:07Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-12-04T08:02:40Z | - |
dc.identifier.citation | Influenza and Other Respiratory Viruses, 17 (10) (Art N° e13202) | - |
dc.identifier.uri | http://hdl.handle.net/1942/41911 | - |
dc.description.abstract | BackgroundTo support the COVID-19 pandemic response, many countries, including Belgium, implemented baseline genomic surveillance (BGS) programs aiming to early detect and characterize new SARS-CoV-2 variants. In parallel, Belgium maintained a sentinel network of six hospitals that samples patients with severe acute respiratory infections (SARI) and integrated SARS-CoV-2 detection within a broader range of respiratory pathogens. We evaluate the ability of the SARI surveillance to monitor general trends and early signals of viral genetic evolution of SARS-CoV-2 and compare it with the BGS as a reference model.MethodsNine-hundred twenty-five SARS-CoV-2 positive samples from patients fulfilling the Belgian SARI definition between January 2020 and December 2022 were sequenced using the ARTIC Network amplicon tiling approach on a MinION platform. Weekly variant of concern (VOC) proportions and types were compared to those that were circulating between 2021 and 2022, using 96,251 sequences of the BGS.ResultsSARI surveillance allowed timely detection of the Omicron (BA.1, BA.2, BA.4, and BA.5) and Delta (B.1.617.2) VOCs, with no to 2 weeks delay according to the start of their epidemic growth in the Belgian population. First detection of VOCs B.1.351 and P.1 took longer, but these remained minor in Belgium. Omicron BA.3 was never detected in SARI surveillance. Timeliness could not be evaluated for B.1.1.7, being already major at the start of the study period.ConclusionsGenomic surveillance of SARS-CoV-2 using SARI sentinel surveillance has proven to accurately reflect VOCs detected in the population and provides a cost-effective solution for long-term genomic monitoring of circulating respiratory viruses. | - |
dc.description.sponsorship | Belgian Federal Government [SEQ-COVID19-LABSURV] | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2023 Sciensano and The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.subject.other | genomic surveillance | - |
dc.subject.other | influenza | - |
dc.subject.other | pandemic preparedness | - |
dc.subject.other | respiratory viruses | - |
dc.subject.other | SARI surveillance | - |
dc.subject.other | SARS-CoV-2 | - |
dc.title | Genomic monitoring of SARS-CoV-2 variants using sentinel SARI hospital surveillance | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 10 | - |
dc.identifier.volume | 17 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Denayer, S (corresponding author), Natl Influenza Ctr, Sciensano, Sci Directorate Infect Dis Humans, Viral Dis, Engelandst 642, B-1180 Uccle, Belgium. | - |
dc.description.notes | sarah.denayer@sciensano.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e13202 | - |
dc.identifier.doi | 10.1111/irv.13202 | - |
dc.identifier.pmid | 37840842 | - |
dc.identifier.isi | 001096122600002 | - |
dc.contributor.orcid | , Sarah/0000-0003-0489-3515; Andre, Emmanuel/0000-0001-8321-3770 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Denayer, Sarah; Dufrasne, Francois E.; Monsieurs, Bert; Van Eycken, Reinout; Barbezange, Cyril; Van Gucht, Steven] Natl Influenza Ctr, Sciensano, Sci Directorate Infect Dis Humans, Viral Dis, Uccle, Belgium. | - |
local.description.affiliation | [Houben, Sarah] Sciensano, Observat Clin Trials, Sci Directorate Infect Dis Humans, Uccle, Belgium. | - |
local.description.affiliation | [Seyler, Lucie; Van Nedervelde, Els] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZB, Dept Internal Med & Infectiol, Brussels, Belgium. | - |
local.description.affiliation | [Demuyser, Thomas] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZB, Dept Microbiol & Infect Control, Brussels, Belgium. | - |
local.description.affiliation | [Demuyser, Thomas] Vrije Univ Brussel VUB, Fac Med & Pharm, Ctr Neurosci, AIMS Lab, Brussels, Belgium. | - |
local.description.affiliation | [Bourgeois, Marc; Delaere, Benedicte] CHU UCL Namur, Yvoir, Belgium. | - |
local.description.affiliation | [Magerman, Koen] Jessa Ziekenhuis, Infect Control & Clin Lab, Hasselt, Belgium. | - |
local.description.affiliation | [Magerman, Koen] Hasselt Univ, Dept Immunol & Infect, Hasselt, Belgium. | - |
local.description.affiliation | [Jouck, Door] Jessa Ziekenhuis, Infect Control, Hasselt, Belgium. | - |
local.description.affiliation | [Lissoir, Benedicte; Sion, Catherine] Grand Hop Charleroi, Lab S St Joseph, Gilly, Belgium. | - |
local.description.affiliation | [Reynders, Marijke; Petit, Evelyn] AZ Sint Jan Brugge Oostende AV, Lab Med, Brugge, Belgium. | - |
local.description.affiliation | [Dauby, Nicolas] Univ Libre Bruxelles ULB, Ctr Hosp Univ St Pierre, Dept Infect Dis, Brussels, Belgium. | - |
local.description.affiliation | [Dauby, Nicolas] Univ Libre Bruxelles ULB, ULB Ctr Res Immunol U CRI, Inst Med Immunol, Brussels, Belgium. | - |
local.description.affiliation | [Dauby, Nicolas] Univ Libre Bruxelles ULB, Sch Publ Hlth, Brussels, Belgium. | - |
local.description.affiliation | [Hainaut, Marc] Univ Libre Bruxelles ULB, CHU St Pierre, Pediat Dept, Brussels, Belgium. | - |
local.description.affiliation | [Laenen, Lies; Cuypers, Lize; Andre, Emmanuel] UZ Leuven, Univ Hosp Leuven, Natl Reference Ctr Resp Pathogens, Leuven, Belgium. | - |
local.description.affiliation | [Laenen, Lies; Cuypers, Lize; Andre, Emmanuel] Katholieke Univ Leuven, Dept Microbiol, Lab Clin Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Maes, Piet; Baele, Guy; Dellicour, Simon] Katholieke Univ Leuven, Rega Inst, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Dellicour, Simon] Univ Libre Bruxelles, Spatial Epidemiol Lab SpELL, Brussels, Belgium. | - |
local.description.affiliation | [Couvreur, Simon; Brondeel, Ruben; Bossuyt, Nathalie] Sciensano, Epidemiol & publ Hlth, Epidemiol Infect Dis, Brussels, Belgium. | - |
local.description.affiliation | [Denayer, Sarah] Natl Influenza Ctr, Sciensano, Sci Directorate Infect Dis Humans, Viral Dis, Engelandst 642, B-1180 Uccle, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | Denayer, Sarah; Dufrasne, Francois E.; Monsieurs, Bert; Van Eycken, Reinout; Houben , Sarah; Seyler, Lucie; Demuyser, Thomas; Van Nedervelde, Els; Bourgeois, Marc; Delaere, Benedicte; MAGERMAN, Koen; Jouck, Door; Lissoir, Benedicte; Sion, Catherine; Reynders , Marijke; Petit, Evelyn; Dauby, Nicolas; Hainaut, Marc; Laenen , Lies; Maes, Piet; Baele, Guy; Dellicour, Simon; Cuypers, Lize; Andre, Emmanuel; Couvreur, Simon; Brondeel, Ruben; Barbezange, Cyril; Bossuyt, Nathalie & Van Gucht, Steven (2023) Genomic monitoring of SARS-CoV-2 variants using sentinel SARI hospital surveillance. In: Influenza and Other Respiratory Viruses, 17 (10) (Art N° e13202). | - |
item.contributor | Denayer, Sarah | - |
item.contributor | Dufrasne, Francois E. | - |
item.contributor | Monsieurs, Bert | - |
item.contributor | Van Eycken, Reinout | - |
item.contributor | Houben , Sarah | - |
item.contributor | Seyler, Lucie | - |
item.contributor | Demuyser, Thomas | - |
item.contributor | Van Nedervelde, Els | - |
item.contributor | Bourgeois, Marc | - |
item.contributor | Delaere, Benedicte | - |
item.contributor | MAGERMAN, Koen | - |
item.contributor | Jouck, Door | - |
item.contributor | Lissoir, Benedicte | - |
item.contributor | Sion, Catherine | - |
item.contributor | Reynders , Marijke | - |
item.contributor | Petit, Evelyn | - |
item.contributor | Dauby, Nicolas | - |
item.contributor | Hainaut, Marc | - |
item.contributor | Laenen , Lies | - |
item.contributor | Maes, Piet | - |
item.contributor | Baele, Guy | - |
item.contributor | Dellicour, Simon | - |
item.contributor | Cuypers, Lize | - |
item.contributor | Andre, Emmanuel | - |
item.contributor | Couvreur, Simon | - |
item.contributor | Brondeel, Ruben | - |
item.contributor | Barbezange, Cyril | - |
item.contributor | Bossuyt, Nathalie | - |
item.contributor | Van Gucht, Steven | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1750-2640 | - |
crisitem.journal.eissn | 1750-2659 | - |
Appears in Collections: | Research publications |
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Influenza Resp Viruses - 2023 - Denayer - Genomic monitoring of SARS‐CoV‐2 variants using sentinel SARI hospital.pdf | Published version | 1.84 MB | Adobe PDF | View/Open |
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