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Title: | Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab | Authors: | BECKERS, Lien BAETEN, Paulien POPESCU, Veronica SWINNEN, Dries CARDILLI, Alessio HAMAD, Ibrahim VAN WIJMEERSCH, Bart Tavernier, S.J. KLEINEWIETFELD, Markus BROUX, Bieke FRAUSSEN, Judith SOMERS, Veerle |
Issue Date: | 2024 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | CLINICAL IMMUNOLOGY, 259 (Art N° 109894) | Abstract: | B cell depletion by the anti-CD20 antibody ocrelizumab is effective in relapsing-remitting (RR) and primary progressive (PP) multiple sclerosis (MS). We investigated immunological changes in peripheral blood of a real- world MS cohort after 6 and 12 months of ocrelizumab. All RRMS and most PPMS patients (15/20) showed treatment response. Ocrelizumab not only reduced CD20+ B cells, but also numbers of CD20+T cells. Absolute numbers of monocytes, dendritic cells and CD8+T cells were increased, while CD56hi natural killer cells were reduced after ocrelizumab. The residual B cell population shifted towards transitional and activated, IgA+ switched memory B cells, double negative B cells, and antibody- secreting cells. Delaying the treatment interval by 2–3 months increased mean B cell frequencies and enhanced naive B cell repopulation. Ocrelizumab reduced plasma levels of interleukin(IL)-12p70 and interferon (IFN)-α2. These findings will contribute to understanding ineffective treatment responses, dealing with life-threatening infections and further unravelling MS pathogenesis. | Notes: | Somers, V (corresponding author), Hasselt Univ, Biomed Res Inst, Martelarenlaan 42, B-3500 Hasselt, Belgium. veerle.somers@uhasselt.be |
Keywords: | Multiple sclerosis;Ocrelizumab;B cells;High-dimensional flow cytometry;Treatment response;Extended interval dosing | Document URI: | http://hdl.handle.net/1942/42154 | ISSN: | 1521-6616 | e-ISSN: | 1521-7035 | DOI: | 10.1016/j.clim.2024.109894 | ISI #: | 001156782600001 | Rights: | 2024TheAuthors.PublishedbyElsevierInc.ThisisanopenaccessarticleundertheCCBYlicense(http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1-s2.0-S1521661624000056-main.pdf | Published version | 3.69 MB | Adobe PDF | View/Open |
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