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http://hdl.handle.net/1942/42174| Title: | A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation | Authors: | Li, Shaobo Spitz, Natalia Ghantous, Akram Abrishamcar, Sarina REIMANN, Brigitte Marques, Irene Silver, Matt J. Aguilar-Lacasaña, Sofía Kitaba, Negusse Rezwan, Faisal I. Röder, Stefan Sirignano, Lea Tuhkanen, Johanna Mancano, Giulia Sharp, Gemma C. Metayer, Catherine Morimoto, Libby Stein, Dan J. Zar, Heather J. ALFANO, Rossella NAWROT, Tim WANG, Congrong Kajantie, Eero Keikkala, Elina Mustaniemi, Sanna Ronkainen, Justiina Sebert, Sylvain Silva, Wnurinham Vääräsmäki, Marja Jaddoe, Vincent W. V. Bernstein, Robin M. Prentice, Andrew M. Cosin-Tomas, Marta Dwyer, Terence Håberg, Siri Eldevik Herceg, Zdenko Magnus, Maria C. Munthe-Kaas, Monica Cheng Page, Christian M. Völker, Maja Gilles, Maria Send, Tabea Witt, Stephanie Zillich, Lea Gagliardi, Luigi Richiardi, Lorenzo Czamara, Darina Räikkönen, Katri Chatzi, Lida Vafeiadi, Marina Arshad, S. Hasan Ewart, Susan PLUSQUIN, Michelle Felix, Janine F. Moore, Sophie E. Vrijheid, Martine Holloway, John W. Karmaus, Wilfried Herberth, Gunda Zenclussen, Ana Streit, Fabian Lahti, Jari Hüls, Anke Hoang, Thanh T. London, Stephanie J. Wiemels, Joseph L. |
Issue Date: | 2024 | Publisher: | NATURE PORTFOLIO | Source: | Communications Biology, 7 (1) (Art N° 66) | Abstract: | Higher birth order is associated with altered risk of many disease states. Changes in pla-centation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epi-genomic states on changing disease incidence trends. | Notes: | Wiemels, JL (corresponding author), Univ Southern Calif, Dept Populat & Publ Hlth Sci, Ctr Genet Epidemiol, Los Angeles, CA USA. wiemels@usc.edu |
Keywords: | Child;Female;Humans;Infant, Newborn;Pregnancy;Epigenesis, Genetic;Epigenomics;Birth Order;DNA Methylation | Document URI: | http://hdl.handle.net/1942/42174 | e-ISSN: | 2399-3642 | DOI: | 10.1038/s42003-023-05698-x | ISI #: | 001139114900008 | Rights: | The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution |
| Appears in Collections: | Research publications |
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| s42003-023-05698-x.pdf | Published version | 1.54 MB | Adobe PDF | View/Open |
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