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http://hdl.handle.net/1942/42293
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DC Field | Value | Language |
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dc.contributor.author | Cuau, Loic | - |
dc.contributor.author | Akl, Pia | - |
dc.contributor.author | Gautheron, A. | - |
dc.contributor.author | Houmeau, Angele | - |
dc.contributor.author | Chaput, Frederic | - |
dc.contributor.author | Yaromina, Ala | - |
dc.contributor.author | Dubois, Ludwig | - |
dc.contributor.author | Lambin, Philippe | - |
dc.contributor.author | Karpati, Szilvia | - |
dc.contributor.author | Parola, Stephane | - |
dc.contributor.author | REZAEIFAR, Behzad | - |
dc.contributor.author | Langlois, Jean-Baptiste | - |
dc.contributor.author | Si-Mohamed, Salim A. | - |
dc.contributor.author | Montcel, Bruno | - |
dc.contributor.author | Douek, Philippe | - |
dc.contributor.author | Lerouge, Frederic | - |
dc.date.accessioned | 2024-02-01T10:45:36Z | - |
dc.date.available | 2024-02-01T10:45:36Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-02-01T10:38:13Z | - |
dc.identifier.citation | Nanoscale, | - |
dc.identifier.uri | http://hdl.handle.net/1942/42293 | - |
dc.description.abstract | X-Ray imaging techniques are among the most widely used modalities in medical imaging and their constant evolution has led to the emergence of new technologies. The new generation of computed tomography (CT) systems - spectral photonic counting CT (SPCCT) and X-ray luminescence optical imaging - are examples of such powerful techniques. With these new technologies the rising demand for new contrast agents has led to extensive research in the field of nanoparticles and the possibility to merge the modalities appears to be highly attractive. In this work, we propose the design of lanthanide-based nanocrystals as a multimodal contrast agent with the two aforementioned technologies, allowing SPCCT and optical imaging at the same time. We present a systematic study on the effect of the Tb3+ doping level and surface modification on the generation of contrast with SPCCT and the luminescence properties of GdF3:Tb3+ nanocrystals (NCs), comparing different surface grafting with organic ligands and coatings with silica to make these NCs bio-compatible. A comparison of the luminescence properties of these NCs with UV revealed that the best results were obtained for the Gd0.9Tb0.1F3 composition. This property was confirmed under X-ray excitation in microCT and with SPCCT. Moreover, we could demonstrate that the intensity of the luminescence and the excited state lifetime are strongly affected by the surface modification. Furthermore, whatever the chemical nature of the ligand, the contrast with SPCCT did not change. Finally, the successful proof of concept of multimodal imaging was performed in vivo with nude mice in the SPCCT taking advantage of the so-called color K-edge imaging method. | - |
dc.description.sponsorship | This work was done in the frame of the SCANnTREAT project, and this project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 899549. Luminescence studies with SPCCT were funded by a public grant from the French National Research Agency (ANR) under the “France 2030” investment plan, which has the reference EUR MANUTECH SLEIGHT – ANR-17-EURE-0026. This work was funded by LABEX PRIMES (ANR-11-LABX-0063) of Université de Lyon, within the program “Investissements d’Avenir” (ANR-11- IDEX-0007), operated by the French National Research Agency ANR). The experiments were based on the work done on the ISO 9001:2015 PILoT facility. The authors thank Dr O. Maury from Chemistry Laboratory for fruitful discussions and help with luminescence measurements, Y. Yagil from Philips company for his strong input on SPCCT technology improvement and R. Biemans from Maastricht university for her work on clonogenic assays. | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.rights | The Royal Society of Chemistry 2023. Open Access Article. Published on 17 January 2024. Downloaded on 2/1/2024 10:40:43 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. | - |
dc.title | Surface modification effect on contrast agent efficiency for X-ray based spectral photoncounting scanner/luminescence imaging: from fundamental study to in vivo proof of concept | - |
dc.type | Journal Contribution | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Lerouge, F (corresponding author), Univ Claude Bernard Lyon 1, Univ Lyon, Ecole Normale Super Lyon, CNRS UMR 5182,Lab Chim, 46 Allee Italie, F-69364 Lyon, France. | - |
dc.description.notes | frederic.lerouge@ens-lyon.fr | - |
local.publisher.place | THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 899549 | - |
dc.identifier.doi | 10.1039/d3nr03710j | - |
dc.identifier.pmid | 38230699 | - |
dc.identifier.isi | 001143951300001 | - |
dc.contributor.orcid | Lambin, Philippe/0000-0001-7961-0191; Parola, | - |
dc.contributor.orcid | Stephane/0000-0001-7560-988X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Cuau, Loic; Chaput, Frederic; Karpati, Szilvia; Parola, Stephane; Lerouge, Frederic] Univ Claude Bernard Lyon 1, Univ Lyon, Ecole Normale Super Lyon, CNRS UMR 5182,Lab Chim, 46 Allee Italie, F-69364 Lyon, France. | - |
local.description.affiliation | [Akl, Pia; Gautheron, A.; Houmeau, Angele; Si-Mohamed, Salim A.; Montcel, Bruno; Douek, Philippe] Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, UJM St Etienne,CNRS,Inserm,CREATIS UMR 5220,U1294, F-69621 Lyon, France. | - |
local.description.affiliation | [Akl, Pia; Si-Mohamed, Salim A.; Douek, Philippe] Hosp Civils Lyon, Dept Radiol, F-69500 Bron, France. | - |
local.description.affiliation | [Gautheron, A.] Univ Jean Monnet St Etienne, Inst Opt Grad Sch, CNRS, Lab Hubert Curien UMR 5516, F-42023 St Etienne, France. | - |
local.description.affiliation | [Yaromina, Ala; Dubois, Ludwig; Lambin, Philippe; Rezaeifar, B.] Maastricht Univ, GROW Sch Oncol, M Lab, Dept Precis Med, NL-6200 MD Maastricht, Netherlands. | - |
local.description.affiliation | [Rezaeifar, B.] Hasselt Univ, Ctr Environm Sci, Res Grp NuTeC, Diepenbeek, Belgium. | - |
local.description.affiliation | [Langlois, Jean-Baptiste] CERMEP Imagerie Vivant, 59 Blvd Pinel, F-69500 Bron, France. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.contributor | Cuau, Loic | - |
item.contributor | Akl, Pia | - |
item.contributor | Gautheron, A. | - |
item.contributor | Houmeau, Angele | - |
item.contributor | Chaput, Frederic | - |
item.contributor | Yaromina, Ala | - |
item.contributor | Dubois, Ludwig | - |
item.contributor | Lambin, Philippe | - |
item.contributor | Karpati, Szilvia | - |
item.contributor | Parola, Stephane | - |
item.contributor | REZAEIFAR, Behzad | - |
item.contributor | Langlois, Jean-Baptiste | - |
item.contributor | Si-Mohamed, Salim A. | - |
item.contributor | Montcel, Bruno | - |
item.contributor | Douek, Philippe | - |
item.contributor | Lerouge, Frederic | - |
item.fullcitation | Cuau, Loic; Akl, Pia; Gautheron, A.; Houmeau, Angele; Chaput, Frederic; Yaromina, Ala; Dubois, Ludwig; Lambin, Philippe; Karpati, Szilvia; Parola, Stephane; REZAEIFAR, Behzad; Langlois, Jean-Baptiste; Si-Mohamed, Salim A.; Montcel, Bruno; Douek, Philippe & Lerouge, Frederic (2024) Surface modification effect on contrast agent efficiency for X-ray based spectral photoncounting scanner/luminescence imaging: from fundamental study to in vivo proof of concept. In: Nanoscale,. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2040-3364 | - |
crisitem.journal.eissn | 2040-3372 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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D3NR03710J 1..14.pdf | Early view | 6.21 MB | Adobe PDF | View/Open |
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