Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/42293
Title: | Surface modification effect on contrast agent efficiency for X-ray based spectral photoncounting scanner/luminescence imaging: from fundamental study to in vivo proof of concept | Authors: | Cuau, Loic Akl, Pia Gautheron, A. Houmeau, Angele Chaput, Frederic Yaromina, Ala Dubois, Ludwig Lambin, Philippe Karpati, Szilvia Parola, Stephane REZAEIFAR, Behzad Langlois, Jean-Baptiste Si-Mohamed, Salim A. Montcel, Bruno Douek, Philippe Lerouge, Frederic |
Issue Date: | 2024 | Publisher: | ROYAL SOC CHEMISTRY | Source: | Nanoscale, | Status: | Early view | Abstract: | X-Ray imaging techniques are among the most widely used modalities in medical imaging and their constant evolution has led to the emergence of new technologies. The new generation of computed tomography (CT) systems - spectral photonic counting CT (SPCCT) and X-ray luminescence optical imaging - are examples of such powerful techniques. With these new technologies the rising demand for new contrast agents has led to extensive research in the field of nanoparticles and the possibility to merge the modalities appears to be highly attractive. In this work, we propose the design of lanthanide-based nanocrystals as a multimodal contrast agent with the two aforementioned technologies, allowing SPCCT and optical imaging at the same time. We present a systematic study on the effect of the Tb3+ doping level and surface modification on the generation of contrast with SPCCT and the luminescence properties of GdF3:Tb3+ nanocrystals (NCs), comparing different surface grafting with organic ligands and coatings with silica to make these NCs bio-compatible. A comparison of the luminescence properties of these NCs with UV revealed that the best results were obtained for the Gd0.9Tb0.1F3 composition. This property was confirmed under X-ray excitation in microCT and with SPCCT. Moreover, we could demonstrate that the intensity of the luminescence and the excited state lifetime are strongly affected by the surface modification. Furthermore, whatever the chemical nature of the ligand, the contrast with SPCCT did not change. Finally, the successful proof of concept of multimodal imaging was performed in vivo with nude mice in the SPCCT taking advantage of the so-called color K-edge imaging method. | Notes: | Lerouge, F (corresponding author), Univ Claude Bernard Lyon 1, Univ Lyon, Ecole Normale Super Lyon, CNRS UMR 5182,Lab Chim, 46 Allee Italie, F-69364 Lyon, France. frederic.lerouge@ens-lyon.fr |
Document URI: | http://hdl.handle.net/1942/42293 | ISSN: | 2040-3364 | e-ISSN: | 2040-3372 | DOI: | 10.1039/d3nr03710j | ISI #: | 001143951300001 | Rights: | The Royal Society of Chemistry 2023. Open Access Article. Published on 17 January 2024. Downloaded on 2/1/2024 10:40:43 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
D3NR03710J 1..14.pdf | Early view | 6.21 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.