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Title: | The prognostic effect of radiological extranodal extension in HPV-positive oropharyngeal squamous cell carcinomas: a retrospective cohort analysis | Authors: | Meulemans, Jeroen Werpin, Louis Hermans , Robert LAENEN, Annouschka Nuyts , Sandra Clement, Paul M. Delaere, Pierre Van Lierde, Charlotte Vander Poorten, Vincent |
Issue Date: | 2024 | Publisher: | SPRINGER | Source: | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, | Status: | Early view | Abstract: | PurposeRadiological extranodal extension (rENE) is a well-known negative prognosticator in head and neck squamous cell carcinoma (HNSCC). However, controversy remains regarding the prognostic effect of rENE in HPV-positive oropharyngeal SCCs (OPSCC). This single-center retrospective cohort analysis assessed the prognostic role of rENE in an HPV + OPSCC population and tried to validate a recently proposed modification of the TNM8 N-classification.Methods129 patients with HPV + OPSCC, of whom 106 cN + patients, were included. Radiological imaging (CT, MRI or both) was reanalyzed by a senior head and neck radiologist. Overall survival (OS), disease-free survival (DFS), locoregional recurrence-free survival (LRFS), and disease-specific survival (DSS) were evaluated. Cox proportional hazard models were used for estimating hazard ratios (HR).ResultsA non-significant trend towards better outcomes in the rENE- group, as compared to the rENE + population, was observed for 5 year OS [80.99% vs 68.70%, HR: 2.05, p = 0.160], 5 year RFS [78.81% vs 67.87%, HR: 1.91, p = 0.165], 5 year DFS [77.06% vs 60.16%, HR: 2.12, p = 0.0824] and 5 year DSS [88.83% vs 81.93%, HR: 2.09, p = 0.195]. OS declined with ascending levels of rENE (p = 0.020). Multivariate analysis identified cT-classification and smoking as independent negative predictors for OS/DFS. The proposed modification of the TNM8 N-classification could not be validated.ConclusionsAlthough rENE could not be identified as an independent negative prognosticator for outcome in our HPV + OPSCC population, outcomes tend to deteriorate with increasing rENE. | Notes: | Meulemans, J (corresponding author), Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Herestr 49, B-3000 Leuven, Belgium.; Meulemans, J (corresponding author), Katholieke Univ Leuven, Dept Oncol Sect Head & Neck Oncol, Leuven, Belgium. jeroen.meulemans@uzleuven.be |
Keywords: | Radiological extranodal extension (rENE);Human papillomavirus (HPV);Oropharyngeal squamous cell carcinoma (OPSCC);Prognostic effect;Outcomes | Document URI: | http://hdl.handle.net/1942/42294 | ISSN: | 0937-4477 | e-ISSN: | 1434-4726 | DOI: | 10.1007/s00405-023-08409-8 | ISI #: | 001135709900002 | Rights: | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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