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http://hdl.handle.net/1942/42679
Title: | Evaluation of Glucose Metrics in Adults with Type 1 Diabetes Switching to Insulin Glargine 300 U/mL: A Retrospective, Propensity-Score Matched Study | Authors: | Charleer, Sara FIEUWS, Steffen De Block, Christophe Bolsens, Nancy Nobels, Frank Mikkelsen, Kristian Mathieu, Chantal Gillard, Pieter |
Issue Date: | 2024 | Publisher: | MARY ANN LIEBERT, INC | Source: | Diabetes Technology & Therapeutics, | Status: | Early view | Abstract: | Objectives: To study real-world effect of switching to Insulin Glargine 300 U/mL (Gla-300) on glucose metrics in people with type 1 diabetes. Methods: This retrospective secondary-use study compared 151 adults who switched to Gla-300 from first-generation long-acting insulins (Switchers) to 281 propensity-score matched controls (Non-switchers) who continued first-generation long-acting insulins. Primary endpoint was difference in time in range (TIR) evolution. A fictive "switching" date was assigned to Non-switchers to facilitate between-group comparisons. Results: In the period before switching, TIR decreased numerically for people in whom Gla-300 was eventually initiated (-0.05%/month [-0.16 to 0.07]), while it increased for matched controls (0.08%/month [0.02 to 0.015]; between-group difference P = 0.047). After Gla-300-initiation, Switchers had similar TIR increase compared to Non-switchers (P = 0.531). Switchers used higher basal dose than before switch (Delta 0.012 U/[kg center dot d] [0.006 to 0.018]; P < 0.0001). Conclusion: In real-life, Gla-300 was typically initiated in people where TIR was decreasing, which was reversed after switch using slightly higher basal insulin dose. | Notes: | Gillard, P (corresponding author), Univ Hosp Leuven, Dept Endocrinol, Herestr 49, B-3000 Leuven, Belgium. pieter.gillard@uzleuven.be |
Keywords: | Type 1 diabetes;Continuous glucose monitoring;Real life;Long-acting insulin | Document URI: | http://hdl.handle.net/1942/42679 | ISSN: | 1520-9156 | e-ISSN: | 1557-8593 | DOI: | 10.1089/dia.2023.0371 | ISI #: | 001180922400001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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