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Title: | 1-Versus 3-Month DAPT in Older Patients at a High Bleeding Risk Undergoing PCI: Insights from the XIENCE Short DAPT Global Program | Authors: | Sardella, Gennaro Spirito, Alessandro Sartori, Samantha Angiolillo, Dominick J. VRANCKX, Pascal Hernandez, Jose M. De la Torre Krucoff, Mitchell W. Bangalore, Sripal Bhatt, Deepak L. Campo, Gianluca Cao, Davide Chehab, Bassem M. Choi, James W. Feng, Yihan Ge, Junbo Godfrey, Katherine Hermiller, James Kunadian, Vijay Makkar, Raj R. Maksoud, Aziz Neumann, Franz-Josef Picon, Hector Saito, Shigeru Thiele, Holger Toelg, Ralph Varenne, Olivier Vogel, Birgit Zhou, Yujie Valgimigli, Marco Windecker, Stephan Mehran, Roxana |
Issue Date: | 2024 | Publisher: | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | Source: | AMERICAN JOURNAL OF CARDIOLOGY, 214 , p. 94 -104 | Abstract: | This analysis aimed to evaluate the effect of 1- versus 3-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in older patients. Data from 3 prospective, single -arm studies (XIENCE Short DAPT Program), including patients with high bleeding risk successfully treated with an everolimus-eluting stent (XIENCE, Abbott) were analyzed. DAPT was discontinued at 1 or at 3 months in patients free from ischemic events and adherent to DAPT. Patients were stratified according to age (>= 75 and <75 years). The primary end point was all-cause death or myocardial infarction (MI). The key secondary end point was Bleeding Academic Research Consortium type 2 to 5 bleeding. The outcomes were assessed from 1 to 12 months after index PCI. Of 3,364 patients, 2,241 (66.6%) were aged >= 75 years. The risk of death or MI was similar with 1- versus 3month DAPT in patients aged >= 75 (8.5% vs 8.0%, adjusted hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.69 to 1.30) and <75 years (6.9% vs 7.8%, adjusted HR 0.97, 95% CI 0.60 to 1.57, interaction p = 0.478). Bleeding Academic Research Consortium type 2 to 5 bleeding was consistently lower with 1- than with 3-month DAPT in patients aged >= 75 years (7.2% vs 9.4%, adjusted HR 0.66, 95% CI 0.48 to 0.91) and <75 years (9.7% vs 11.9%, adjusted HR 0.86, 95% CI 0.57 to 1.29, interaction p = 0.737). In conclusion, in patients at high bleeding risk who underwent PCI, patients older and younger than 75 years derived a consistent benefit from 1- compared with 3-month DAPT in terms of bleeding reduction, with no increase in all-cause death or MI at 1 year. (c) 2024 Elsevier Inc. All rights reserved. | Notes: | Mehran, R (corresponding author), Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA. Roxana.mehran@mountsinai.org |
Keywords: | percutaneous coronary intervention;high bleeding risk;elderly;dual antiplatelet therapy | Document URI: | http://hdl.handle.net/1942/42934 | ISSN: | 0002-9149 | e-ISSN: | 1879-1913 | DOI: | 10.1016/j.amjcard.2023.12.049 | ISI #: | 001195263700001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1- Versus 3-Month DAPT in Older Patients at a High Bleeding Risk Undergoing .pdf Restricted Access | Published version | 1.37 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf Until 2024-09-01 | Peer-reviewed author version | 1.47 MB | Adobe PDF | View/Open Request a copy |
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