Exploring the Pareto front of multi-objective COVID-19 mitigation policies using reinforcement learning

Abstract

Infectious disease outbreaks can have a disruptive impact on public health and societal processes. As decisionmaking in the context of epidemic mitigation is multi -dimensional hence complex, reinforcement learning in combination with complex epidemic models provides a methodology to design refined prevention strategies. Current research focuses on optimizing policies with respect to a single objective, such as the pathogen's attack rate. However, as the mitigation of epidemics involves distinct, and possibly conflicting, criteria (i.a., mortality, morbidity, economic cost, well-being), a multi -objective decision approach is warranted to obtain balanced policies. To enhance future decision -making, we propose a deep multi -objective reinforcement learning approach by building upon a state-of-the-art algorithm called Pareto Conditioned Networks (PCN) to obtain a set of solutions for distinct outcomes of the decision problem. We consider different deconfinement strategies after the first Belgian lockdown within the COVID-19 pandemic and aim to minimize both COVID-19 cases (i.e., infections and hospitalizations) and the societal burden induced by the mitigation measures. As such, we connected a multi -objective Markov decision process with a stochastic compartment model designed to approximate the Belgian COVID-19 waves and explore reactive strategies. As these social mitigation measures are implemented in a continuous action space that modulates the contact matrix of the age -structured epidemic model, we extend PCN to this setting. We evaluate the solution set that PCN returns, and observe that it explored the whole range of possible social restrictions, leading to high -quality trade-offs, as it captured the problem dynamics. In this work, we demonstrate that multi -objective reinforcement learning adds value to epidemiological modeling and provides essential insights to balance mitigation policies.