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Title: | Exploring mitochondrial heteroplasmy in neonates: implications for growth patterns and overweight in the first years of life | Authors: | COSEMANS, Charlotte ALFANO, Rossella SLEURS, Hanne MARTENS, Dries NAWROT, Tim PLUSQUIN, Michelle |
Issue Date: | 2024 | Publisher: | SPRINGERNATURE | Source: | INTERNATIONAL JOURNAL OF OBESITY, | Status: | Early view | Abstract: | Background: Mitochondrial heteroplasmy reflects genetic diversity within individuals due to the presence of varying mitochondrial DNA (mtDNA) sequences, possibly affecting mitochondrial function and energy production in cells. Rapid growth during early childhood is a critical development with long-term implications for health and well-being. In this study, we investigated if cord blood mtDNA heteroplasmy is associated with rapid growth at 6 and 12 months and overweight in childhood at 4-6 years. Methods: This study included 200 mother-child pairs of the ENVIRONAGE birth cohort. Whole mitochondrial genome sequencing was performed to determine mtDNA heteroplasmy levels (in variant allele frequency; VAF) in cord blood. Rapid growth was defined for each child as the difference between WHO-SD scores of predicted weight at either 6 or 12 months and birth weight. Logistic regression models were used to determine the association of mitochondrial heteroplasmy with rapid growth and childhood overweight. Determinants of relevant cord blood mitochondrial heteroplasmies were identified using multiple linear regression models. Results: One % increase in VAF of cord blood MT-D-Loop16362T > C heteroplasmy was associated with rapid growth at 6 months (OR = 1.03; 95% CI: 1.01-1.05; p = 0.001) and 12 months (OR = 1.02; 95% CI: 1.00-1.03; p = 0.02). Furthermore, this variant was associated with childhood overweight at 4-6 years (OR = 1.01; 95% CI 1.00-1.02; p = 0.05). Additionally, rapid growth at 6 months (OR = 3.00; 95% CI: 1.49-6.14; p = 0.002) and 12 months (OR = 4.05; 95% CI: 2.06-8.49; p < 0.001) was also associated with childhood overweight at 4-6 years. Furthermore, we identified maternal age, pre-pregnancy BMI, maternal education, parity, and gestational age as determinants of cord blood MT-D-Loop16362T > C heteroplasmy. Conclusions: Our findings, based on mitochondrial DNA genotyping, offer insights into the molecular machinery leading to rapid growth in early life, potentially explaining a working mechanism of the development toward childhood overweight. | Notes: | Plusquin, M (corresponding author), Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. michelle.plusquin@uhasselt.be |
Document URI: | http://hdl.handle.net/1942/43088 | ISSN: | 0307-0565 | e-ISSN: | 1476-5497 | DOI: | 10.1038/s41366-024-01537-z | ISI #: | 001232140400001 | Rights: | The Author(s), under exclusive licence to Springer Nature Limited 2024 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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s41366-024-01537-z.pdf Restricted Access | Early view | 913.52 kB | Adobe PDF | View/Open Request a copy |
Cosemans et al. 2024 IJO.pdf Until 2024-11-27 | Peer-reviewed author version | 435.93 kB | Adobe PDF | View/Open Request a copy |
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