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Title: | Tailoring Network Topology in Mechanically Robust Hydrogels for 3D Printing and Injection | Authors: | EBRAHIMI, Mahsa ARREGUIN CAMPOS, Mariana Dookhith, Aaliyah Z. Aldana, Ana A. Lynd, Nathaniel A. Sanoja, Gabriel E. Baker, Matthew B. PITET, Louis |
Issue Date: | 2024 | Publisher: | AMER CHEMICAL SOC | Source: | ACS Applied Materials & Interfaces, 16 (19) , p. 25353 -25365 | Abstract: | Tissue engineering and regenerative medicine are confronted with a persistent challenge: the urgent demand for robust, load-bearing, and biocompatible scaffolds that can effectively endure substantial deformation. Given that inadequate mechanical performance is typically rooted in structural deficiencies-specifically, the absence of energy dissipation mechanisms and network uniformity-a crucial step toward solving this problem is generating synthetic approaches that enable exquisite control over network architecture. This work systematically explores structure-property relationships in poly(ethylene glycol)-based hydrogels constructed utilizing thiol-yne chemistry. We systematically vary polymer concentration, constituent molar mass, and cross-linking protocols to understand the impact of architecture on hydrogel mechanical properties. The network architecture was resolved within the molecular model of Rubinstein-Panyukov to obtain the densities of chemical cross-links and entanglements. We employed both nucleophilic and radical pathways, uncovering notable differences in mechanical response, which highlight a remarkable degree of versatility achievable by tuning readily accessible parameters. Our approach yielded hydrogels with good cell viability and remarkably robust tensile and compression profiles. Finally, the hydrogels are shown to be amenable to advanced processing techniques by demonstrating injection- and extrusion-based 3D printing. Tuning the mechanism and network regularity during the cell-compatible formation of hydrogels is an emerging strategy to control the properties and processability of hydrogel biomaterials by making simple and rational design choices. | Notes: | Pitet, LM (corresponding author), Hasselt Univ, Inst Mat Res Imo Imomec, Adv Funct Polymers AFP Lab, B-3500 Hasselt, Belgium.; Baker, MB (corresponding author), Maastricht Univ, Dept Instructive Biomat Engn, MERLN Inst Technol Inspired Regenerat Med, NL-6229 ET Maastricht, Netherlands.; Baker, MB (corresponding author), Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, NL-6229 ET Maastricht, Netherlands. m.baker@maastrichtuniversity.nl; louis.pitet@uhasselt.be |
Keywords: | 3D fabrication;hydrogels;network topology;hydrogel injection;tissue engineering | Document URI: | http://hdl.handle.net/1942/43102 | ISSN: | 1944-8244 | e-ISSN: | 1944-8252 | DOI: | 10.1021/acsami.4c03209 | ISI #: | 001225123200001 | Rights: | 2024 American Chemical Society | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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ebrahimi-et-al-2024-tailoring-network-topology-in-mechanically-robust-hydrogels-for-3d-printing-and-injection.pdf Restricted Access | Published version | 9.73 MB | Adobe PDF | View/Open Request a copy |
EBRM-3-Manuscript vFinal_ACS_Clean.pdf Until 2024-11-07 | Peer-reviewed author version | 12.85 MB | Adobe PDF | View/Open Request a copy |
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