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http://hdl.handle.net/1942/43148
Title: | Design of a clinical trial using generalized pairwise comparisons to test a less intensive treatment regimen | Authors: | Backer, MD Sengar, M Mathews, V Salvaggio, S DELTUVAITE-THOMAS, Vaiva Chiem, JC Saad, ED BUYSE, Marc |
Issue Date: | 2024 | Publisher: | SAGE PUBLICATIONS LTD | Source: | Clinical Trials, 21 (2) , p. 180 -188 | Abstract: | Showing "similar efficacy" of a less intensive treatment typically requires a non-inferiority trial. Yet such trials may be challenging to design and conduct. In acute promyelocytic leukemia, great progress has been achieved with the introduction of targeted therapies, but toxicity remains a major clinical issue. There is a pressing need to show the favorable benefit/risk of less intensive treatment regimens. | Keywords: | Generalized pairwise comparisons;prioritized outcomes;net treatment benefit;non-inferiority;benefit/risk;acute promyelocytic leukemia | Document URI: | http://hdl.handle.net/1942/43148 | ISSN: | 1740-7745 | e-ISSN: | 1740-7753 | DOI: | 10.1177/17407745231206465 | ISI #: | 001087484500001 | Rights: | The Author(s) 2023 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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backer-et-al-2023-design-of-a-clinical-trial-using-generalized-pairwise-comparisons-to-test-a-less-intensive-treatment.pdf | Published version | 1.79 MB | Adobe PDF | View/Open |
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