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http://hdl.handle.net/1942/43298
Title: | Genomic stress and impaired DNA repair in Alzheimer disease | Authors: | Neven, Dolien ISSAYAMA, Luidy DEWACHTER, Ilse WILSON, David |
Issue Date: | 2024 | Publisher: | ELSEVIER | Source: | DNA repair (Print), 139 (Art N° 103678) | Abstract: | Alzheimer disease (AD) is the most prominent form of dementia and has received considerable attention due to its growing burden on economic, healthcare and basic societal infrastructures. The two major neuropathological hallmarks of AD, i.e., extracellular amyloid beta (A beta) peptide plaques and intracellular hyperphosphorylated Tau neurofibrillary tangles, have been the focus of much research, with an eye on understanding underlying disease mechanisms and identifying novel therapeutic avenues. One often overlooked aspect of AD is how A beta and Tau may, through indirect and direct mechanisms, affect genome integrity. Herein, we review evidence that A beta and Tau abnormalities induce excessive genomic stress and impair genome maintenance mechanisms, events that can promote DNA damage-induced neuronal cell loss and associated brain atrophy. | Notes: | Wilson, DM (corresponding author), Hasselt Univ, Biomed Res Inst, BIOMED, B-3500 Hasselt, Belgium. david.wilson@uhasselt.be |
Keywords: | Alzheimer disease;DNA damage;DNA repair;Amyloid beta;Tau;Neurodegeneration | Document URI: | http://hdl.handle.net/1942/43298 | ISSN: | 1568-7864 | e-ISSN: | 1568-7856 | DOI: | 10.1016/j.dnarep.2024.103678 | ISI #: | 001233922100001 | Rights: | 2024 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Genomic stress and impaired DNA repair in Alzheimer disease.pdf Restricted Access | Published version | 2.02 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf Until 2025-01-01 | Peer-reviewed author version | 1.26 MB | Adobe PDF | View/Open Request a copy |
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