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Title: | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso | Authors: | Hanley-Cook, Giles T. Bastos-Moreira, Yuri MARTENS, Dries Dailey-Chwalibóg, Trenton Toe, Laeticia Celine Kok, Brenda de Ouédraogo, Lionel Argaw, Alemayehu Tesfamariam, Kokeb Kolsteren, Patrick Huybregts, Lieven NAWROT, Tim Saeger, Sarah De Boevre, Marthe De Lachat, Carl |
Issue Date: | 2024 | Publisher: | Source: | Food Science and Human Wellness, 15 | Status: | Early view | Abstract: | Background: Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease, such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives: We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome. Design: We conducted a randomized controlled trial in rural Burkina Faso, among pregnant females (15−40 years old) enrolled at < 21 weeks of gestation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants, respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms. Results: We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β = -0.010 (95% CI: -0.057, 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI: -0.203, 0.073); | Keywords: | balanced-energy protein;Burkina Faso;iron-folic acid;mitochondrial DNA;multiple micronutrients;randomized controlled trial;telomere length | Document URI: | http://hdl.handle.net/1942/43590 | e-ISSN: | 2213-4530 | DOI: | 10.26599/FSHW.2024.9250304 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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