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Title: | Smouldering-Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions | Authors: | Scalfari, Antonio Traboulsee, Anthony Oh, Jiwon Airas, Laura Bittner, Stefan Calabrese, Massimiliano Garcia Dominguez, Jose Manuel Granziera, Cristina Greenberg, Benjamin Hellwig, Kerstin Illes, Zsolt Lycke, Jan POPESCU, Veronica Bagnato, Francesca Giovannoni, Gavin |
Issue Date: | 2024 | Publisher: | WILEY | Source: | Annals of neurology, | Status: | Early view | Abstract: | Despite therapeutic suppression of relapses, multiple sclerosis (MS) patients often experience subtle deterioration, which extends beyond the definition of "progression independent of relapsing activity." We propose the concept of smouldering-associated-worsening (SAW), encompassing physical and cognitive symptoms, resulting from smouldering pathological processes, which remain unmet therapeutic targets. We provide a consensus-based framework of possible pathological substrates and manifestations of smouldering MS, and we discuss clinical, radiological, and serum/cerebrospinal fluid biomarkers for potentially monitoring SAW. Finally, we share considerations for optimizing disease surveillance and implications for clinical trials to promote the integration of smouldering MS into routine practice and future research efforts. ANN NEUROL 2024 image | Notes: | Scalfari, A (corresponding author), Charing Cross Hosp, Ctr Neurosci, Dept Med, Imperial Coll Fulham Palace Rd, London W6 8RF, England. a.scalfari@imperial.ac.uk |
Document URI: | http://hdl.handle.net/1942/43617 | ISSN: | 0364-5134 | e-ISSN: | 1531-8249 | DOI: | 10.1002/ana.27034 | ISI #: | 001275591200001 | Rights: | 2024 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Annals of Neurology - 2024 - Scalfari - SmoulderingāAssociated Worsening in Multiple Sclerosis An International Consensus.pdf | Early view | 2.71 MB | Adobe PDF | View/Open |
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