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Title: | Retinal Vessel Functional Responses in South Africans Living With and Without HIV: The EndoAfrica-NWU Study | Authors: | Myburgh-Jacobsz, Catharina Elizabeth Botha-Le Roux, Shani Kotliar, Konstantin Wentzel, Annemarie Jacobs , Adriaan DE BOEVER, Patrick Goswami, Nandu Strijdom, Hans Smith, Wayne |
Issue Date: | 2024 | Publisher: | WILEY | Source: | Microcirculation (new York, N.y. 1994), (Art N° e12878) | Status: | Early view | Abstract: | Objectives The effects of HIV and antiretroviral therapy (ART) on microvascular function are poorly explored. We compared retinal vessel functional responses to flicker light-induced provocation (FLIP) in people living with HIV (PLWH) and people living without HIV (PLWoutH). Methods We included 115 PLWH and 51 PLWoutH with a median age of 41 years. Treated PLWH received similar first-line fixed-dose combination ART. Clinical characteristics and retinal vessels functional responses to FLIP were compared in (a) PLWH and PLWoutH; and (b) PLWH groups stratified by the median of (i) CD4-count (511 cells/mm3), (ii) viral load (50 copies/mL), and (iii) ART duration (57.6 months). Results PLWH were older, smoked more, and had a lower prevalence of hypertension than PLWoutH (p < 0.05). Almost 64% of PLWH were infected for more than 5 years. Retinal vessel responses to FLIP were similar between PLWH and PLWoutH after taking confounders into account. In addition, PLWH subgroups stratified according to immuno-virological status by CD4-count, viral load, and ART duration showed no differences in retinal vessel responses to FLIP. Conclusion Living with HIV and receiving ART were not associated with altered microvascular function as assessed with dynamic retinal vessel analysis in a South African case-control study. | Notes: | Smith, W (corresponding author), North West Univ, Fac Hlth Sci, Hypertens Africa Res Team HART, Potchefstroom, South Africa.; Smith, W (corresponding author), North West Univ, MRC Res Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa. wayne.smith@nwu.ac.za |
Keywords: | antiretroviral therapy;flicker light provocation;human immunodeficiency virus;retinal vessel analysis | Document URI: | http://hdl.handle.net/1942/43712 | ISSN: | 1073-9688 | e-ISSN: | 1549-8719 | DOI: | 10.1111/micc.12878 | ISI #: | 001285266200001 | Rights: | 2024 The Author(s). Microcirculation published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Microcirculation - 2024.pdf | Early view | 941.52 kB | Adobe PDF | View/Open |
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