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Title: Intention-to-treat
Authors: MOLENBERGHS, Geert 
Issue Date: 2005
Publisher: Wiley
Source: Everitt, Brian S.; Howell, David (Ed.); Encyclopedia of statistics in behavioral sciences, (v2), p. 928-929.
Abstract: The randomized clinical trial paradigm is sketched, as well as the foundations on which its validity is based. Issues that jeopardize this validity, such as patient noncompliance and early withdrawal, are discussed. Intention to treat, being an important historical answer to this problem, is introduced, together with a set of criticisms and an indication of alternative approaches.
Keywords: as-treated analysis;clinical trial;incomplete data;last observation carried forward;randomization
Document URI:
ISBN: 9780470860809
DOI: 10.1002/0470013192.bsa305
Rights: Copyright © 2005 John Wiley & Sons, Ltd
Category: B3
Type: Book Section
Appears in Collections:Research publications

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