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http://hdl.handle.net/1942/44256
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DC Field | Value | Language |
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dc.contributor.author | SLAETS, Leen | - |
dc.contributor.author | VEENINGEN, Naomi | - |
dc.contributor.author | de Keizer, Peter L. J. | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | HENDRIX, Sven | - |
dc.date.accessioned | 2024-09-17T08:13:37Z | - |
dc.date.available | 2024-09-17T08:13:37Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2024-09-09T14:02:51Z | - |
dc.identifier.citation | Aging cell (Print), | - |
dc.identifier.uri | http://hdl.handle.net/1942/44256 | - |
dc.description.abstract | Loss of proper T-cell functioning is a feature of aging that increases the risk of developing chronic diseases. In aged individuals, highly differentiated T cells arise with a reduced expression of CD28 and CD27 and an increased expression of KLRG-1 or CD57. These cells are often referred to as immunosenescent T cells but may still be highly active and contribute to autoimmunity. Another population of T cells known as exhausted T cells arises after chronic antigen stimulation and loses its effector functions, leading to a failure to combat malignancies and viral infections. A process called cellular senescence also increases during aging, and targeting this process has proven to be fruitful against a range of age-related pathologies in animal models. Cellular senescence occurs in cells that are irreparably damaged, limiting their proliferation and typically leading to chronic secretion of pro-inflammatory factors. To develop therapies against pathologies caused by defective T-cell function, it is important to understand the differences and similarities between immunosenescence and cellular senescence. Here, we review the hallmarks of cellular senescence versus senescent and exhausted T cells and provide considerations for the development of specific therapies against age-related diseases. This review delineates the molecular hallmarks of cellular senescence and examines whether they are evident in aging-associated T cells referred to as immunosenescent T cells and exhausted T cells.image | - |
dc.description.sponsorship | S.H. and N.H. received grants (G0C2120FWO and G040321FWO) from the Flemish Fund for Scientific Research (FWO Vlaanderen). N.H. and H.S. were also supported by the Interreg Euregio MeuseRine Healthy Aging project grant (EMR51), funded by the European Fund for Regional Development of the EU, supporting innovation in this region. Figures were created with BioRender.com | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited | - |
dc.subject.other | exhaustion-T-lymphocytes | - |
dc.subject.other | immunosenescence-aging | - |
dc.subject.other | senescence | - |
dc.subject.other | T-cells | - |
dc.title | Are immunosenescent T cells really senescent? | - |
dc.type | Journal Contribution | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hellings, N (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Neuroimmune Connect & Repair Lab, Diepenbeek, Belgium. | - |
dc.description.notes | niels.hellings@uhasselt.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1111/acel.14300 | - |
dc.identifier.isi | 001285895100001 | - |
dc.contributor.orcid | de Keizer, Peter L.J./0000-0002-6948-925X; Slaets, | - |
dc.contributor.orcid | Helena/0000-0002-9629-436X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Slaets, Helena; Veeningen, Naomi; Hellings, Niels] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Neuroimmune Connect & Repair Lab, Diepenbeek, Belgium. | - |
local.description.affiliation | [Slaets, Helena; Veeningen, Naomi; Hellings, Niels] UMSC Univ MS Ctr, Campus Diepenbeek, Diepenbeek, Belgium. | - |
local.description.affiliation | [de Keizer, Peter L. J.] Univ Med Ctr Utrecht, Ctr Mol Med, Utrecht, Netherlands. | - |
local.description.affiliation | [Hendrix, Sven] Med Sch Hamburg, Inst Translat Med, Hamburg, Germany. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.contributor | SLAETS, Leen | - |
item.contributor | VEENINGEN, Naomi | - |
item.contributor | de Keizer, Peter L. J. | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | HENDRIX, Sven | - |
item.fullcitation | SLAETS, Leen; VEENINGEN, Naomi; de Keizer, Peter L. J.; HELLINGS, Niels & HENDRIX, Sven (2024) Are immunosenescent T cells really senescent?. In: Aging cell (Print),. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1474-9718 | - |
crisitem.journal.eissn | 1474-9726 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Aging Cell - 2024 - Slaets - Are immunosenescent T cells really senescent.pdf | Early view | 1.15 MB | Adobe PDF | View/Open |
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