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Title: | Newborn glomerular function and gestational particulate air pollution | Authors: | RASKING, Leen VAN PEE, Thessa VANGENEUGDEN, Maartje RENAERS, Eleni WANG, Congrong PENDERS, Joris De Vusser, Katrien PLUSQUIN, Michelle NAWROT, Tim |
Issue Date: | 2024 | Publisher: | ELSEVIER | Source: | EBioMedicine (Amsterdam), 107 (Art N° 105253) | Abstract: | Background Nephron number variability may hold significance in the Developmental Origins of Health and Disease hypothesis. We explore the impact of gestational particulate pollution exposure on cord blood cystatin C, a marker for glomerular function, as an indicator for glomerular health at birth. Methods From February 2010 onwards, the ENVIRONAGE cohort includes over 2200 mothers giving birth at the East-Limburg hospital in Genk, Belgium. Mothers without planned caesarean section who are able to fill out a Dutch questionnaire are eligible. Here, we evaluated cord blood cystatin C levels from 1484 mother-child pairs participating in the ENVIRONAGE cohort. We employed multiple linear regression models and distributed lag models to assess the association between cord blood cystatin C and gestational particulate air pollution exposure. Findings Average +/- SD levels of cord blood cystatin C levels amounted to 2.16 +/- 0.35 mg/L. Adjusting for covariates, every 0.5 mu g/m(3) and 5 mu g/m(3) increment in gestational exposure to black carbon (BC) and fine particulate matter (PM2.5) corresponded to increases of 0.04 mg/L (95% CI 0.01-0.07) and 0.07 mg/L (95% CI 0.03-0.11) in cord blood cystatin C levels (p < 0.01), respectively. Third-trimester exposure showed similar associations, with a 0.04 mg/L (95% CI 0.00-0.08) and 0.06 mg/L (95% CI 0.04-0.09) increase for BC and PM2.5 (p < 0.02). No significant associations were observed when considering only the first and second trimester exposure. Interpretation Our findings indicate that particulate air pollution during the entire pregnancy, with the strongest effect sizes from week 27 onwards, may affect newborn kidney function, with potential long-term implications for later health. | Notes: | Nawrot, TS (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. tim.nawrot@uhasselt.be |
Keywords: | Air pollution;Fine particulate matter;Black carbon;Cystatin C;Cord blood | Document URI: | http://hdl.handle.net/1942/44279 | ISSN: | 2352-3964 | e-ISSN: | 2352-3964 | DOI: | 10.1016/j.ebiom.2024.105253 | ISI #: | 001302113400001 | Rights: | 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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