Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/45786
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dc.contributor.authorVOLDERS, Pieter-Jan-
dc.contributor.authorAftimos, Philippe-
dc.contributor.authorDedeurwaerdere, Franceska-
dc.contributor.authorMartens, Geert-
dc.contributor.authorCanon, Jean-Luc-
dc.contributor.authorBeniuga, Gabriela-
dc.contributor.authorVan Huysse, Jacques-
dc.contributor.authorFROYEN, Guy-
dc.contributor.authorDe Pauw, Rebecca-
dc.contributor.authorPrenen, Hans-
dc.contributor.authorLambin, Suzan-
dc.contributor.authorDecoster, Lore-
dc.contributor.authorVaeyens, Freya-
dc.contributor.authorRottey, Sylvie-
dc.contributor.authorVan Dam, Pieter-Jan-
dc.contributor.authorDecoster, Lynn-
dc.contributor.authorRutten, Annemie-
dc.contributor.authorSchreuer, Max-
dc.contributor.authorLoontiens, Siebe-
dc.contributor.authorvan der Meulen, Joni-
dc.contributor.authorMEBIS, Jeroen-
dc.contributor.authorCUPPENS, Kristof-
dc.contributor.authorTejpar, Sabine-
dc.contributor.authorVanden Bempt, Isabelle-
dc.contributor.authorDe Greve, Jacques-
dc.contributor.authorSchroeder, David-
dc.contributor.authorvan Marcke, Cedric-
dc.contributor.authorvan den Bulcke, Marc-
dc.contributor.authorde Azambuja, Evandro-
dc.contributor.authorPunie, Kevin-
dc.contributor.authorMAES, Brigitte-
dc.date.accessioned2025-04-01T13:11:39Z-
dc.date.available2025-04-01T13:11:39Z-
dc.date.issued2025-
dc.date.submitted2025-03-24T13:10:13Z-
dc.identifier.citationNpj Precision Oncology, 9 (1) (Art N° 66)-
dc.identifier.urihttp://hdl.handle.net/1942/45786-
dc.description.abstractThe Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study assessed the feasibility of using comprehensive genomic profiling (CGP) in clinical decision-making for patients with advanced cancers. This multi-center study enrolled 872 patients from 12 Belgian hospitals. CGP was performed on tumor tissues using a standardized CGP panel (523 genes) across nine laboratories with success in 93% of patients and a median turnaround time of 29 days. Actionable genomic markers were identified in 81% of patients, substantially higher than the 21% using nationally reimbursed, small panels. A national molecular tumor board (nMTB) recommended treatments for 69% of patients, with 23% receiving matched therapies. Reasons for non-compliance were highly variable across clinical sites. Overall, BALLETT demonstrates the feasibility of implementing decentralized CGP and its potential to identify actionable targets in most patients with advanced cancers. BALLETT reinforces CGP's utility and emphasizes the importance of collaboration, standardization, and addressing implementation challenges.-
dc.description.sponsorshipWe thank all of the patients for their participation as well as all study teams, NGS laboratory personnel, nMTB members, and Sciensano coworkers for their contributions. This work is funded by the European Union (Can.Heal–grant number 101080009). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or HaDEA. Neither the European Union nor the granting authority can be held responsible for them. This study was also funded by grants from Illumina, Inc., and OncoDNA (no grant numbers). These funders played no role in the study design, data collection, analysis, and interpretation of data, or the writing of this manuscript. We would like to acknowledge Matthijs Vynck for designing the SRRS tool and Annick Daniels for creating the BALLETT-app.-
dc.language.isoen-
dc.publisherNATURE PORTFOLIO-
dc.rightsThe Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.-
dc.titleA nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume9-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notesMaes, B (corresponding author), Jessa Hosp, Lab Mol Diagnost, Hasselt, Belgium.; Maes, B (corresponding author), Univ Hasselt, Fac Med & Life Sci, LCRC, Hasselt, Belgium.-
dc.description.notesBrigitte.maes@jessazh.be-
local.publisher.placeHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr66-
dc.identifier.doi10.1038/s41698-025-00858-0-
dc.identifier.pmid40065106-
dc.identifier.isi001441014500001-
local.provider.typewosris-
local.description.affiliation[Volders, Pieter-Jan; Froyen, Guy; Maes, Brigitte] Jessa Hosp, Lab Mol Diagnost, Hasselt, Belgium.-
local.description.affiliation[Volders, Pieter-Jan; Froyen, Guy; Mebis, Jeroen; Cuppens, Kristof; Maes, Brigitte] Univ Hasselt, Fac Med & Life Sci, LCRC, Hasselt, Belgium.-
local.description.affiliation[Volders, Pieter-Jan; Loontiens, Siebe; van der Meulen, Joni] Univ Ghent, Dept Biomol Med, Ghent, Belgium.-
local.description.affiliation[Aftimos, Philippe] Univ Libre Bruxelles, Hop Univ Bruxelles, Inst Jules Bordet, Clin Trials Conduct Unit, Brussels, Belgium.-
local.description.affiliation[Dedeurwaerdere, Franceska] AZ Delta Hosp, Dept Pathol, Roeselare, Belgium.-
local.description.affiliation[Martens, Geert] AZ Delta Hosp Roeselare, Dept Lab Med, Roeselare, Belgium.-
local.description.affiliation[Canon, Jean-Luc; Schroeder, David] Grand Hop Charleroi, Dept Med Oncol, Charleroi, Belgium.-
local.description.affiliation[Beniuga, Gabriela] Inst Pathol & Genet, Charleroi, Belgium.-
local.description.affiliation[Van Huysse, Jacques] AZ Sint Jan Brugge, Dept Pathol, Brugge, Belgium.-
local.description.affiliation[De Pauw, Rebecca] AZ Sint Jan Brugge, Dept Pulmonol, Brugge, Belgium.-
local.description.affiliation[Prenen, Hans] Antwerp Univ Hosp, Dept Oncol, Edegem, Belgium.-
local.description.affiliation[Prenen, Hans] Univ Antwerp, Ctr Oncol Res CORE, B-2020 Antwerp, Belgium.-
local.description.affiliation[Lambin, Suzan] Univ Hosp Antwerp, Dept Pathol, Edegem, Belgium.-
local.description.affiliation[Decoster, Lore] Univ Hosp Brussels, Dept Med Oncol, Brussels, Belgium.-
local.description.affiliation[Decoster, Lore; De Greve, Jacques] Vrije Univ Brussel, Lab Med & Mol Oncol, Brussels, Belgium.-
local.description.affiliation[Vaeyens, Freya; De Greve, Jacques] Univ Hosp Brussels, Ctr Med Genet, Brussels, Belgium.-
local.description.affiliation[Rottey, Sylvie] Univ Ghent, Dept Med Oncol, Ghent, Belgium.-
local.description.affiliation[Van Dam, Pieter-Jan] Cellcarta, Antwerp, Belgium.-
local.description.affiliation[Decoster, Lynn] AZ Turnhout, Dept Pulmonol, Turnhout, Belgium.-
local.description.affiliation[Rutten, Annemie; Punie, Kevin] ZAS Hosp, Dept Med Oncol, Antwerp, Belgium.-
local.description.affiliation[Schreuer, Max] ASZ Aalst, Dept Med Oncol, Aalst, Belgium.-
local.description.affiliation[Loontiens, Siebe; van der Meulen, Joni] Ghent Univ Hosp, Mol Diagnost, Ghent, Belgium.-
local.description.affiliation[Loontiens, Siebe; van der Meulen, Joni] Univ Ghent, Canc Res Inst Ghent, Ghent, Belgium.-
local.description.affiliation[Mebis, Jeroen] Jessa Hosp, Dept Med Oncol, Hasselt, Belgium.-
local.description.affiliation[Cuppens, Kristof] Jessa Hosp, Dept Pulmonol & Thorac Oncol, Hasselt, Belgium.-
local.description.affiliation[Tejpar, Sabine] Katholieke Univ Leuven, Univ Hosp, Leuven, Belgium.-
local.description.affiliation[Vanden Bempt, Isabelle] Univ Hosp KU Leuven, Dept Human Genet, Leuven, Belgium.-
local.description.affiliation[van Marcke, Cedric] UCLouvain, Inst Expt & Clin Res, Brussels, Belgium.-
local.description.affiliation[van Marcke, Cedric] Clin Univ St Luc, Inst Roi Albert II, Dept Med Oncol, Brussels, Belgium.-
local.description.affiliation[van den Bulcke, Marc] Sciensano, B-1050 Brussels, Belgium.-
local.description.affiliation[de Azambuja, Evandro] Hop Univ Bruxelles, Inst Jules Bordet, Brussels, Belgium.-
local.description.affiliation[de Azambuja, Evandro] Univ Libre Bruxelles, Brussels, Belgium.-
local.uhasselt.internationalno-
item.fulltextWith Fulltext-
item.contributorVOLDERS, Pieter-Jan-
item.contributorAftimos, Philippe-
item.contributorDedeurwaerdere, Franceska-
item.contributorMartens, Geert-
item.contributorCanon, Jean-Luc-
item.contributorBeniuga, Gabriela-
item.contributorVan Huysse, Jacques-
item.contributorFROYEN, Guy-
item.contributorDe Pauw, Rebecca-
item.contributorPrenen, Hans-
item.contributorLambin, Suzan-
item.contributorDecoster, Lore-
item.contributorVaeyens, Freya-
item.contributorRottey, Sylvie-
item.contributorVan Dam, Pieter-Jan-
item.contributorDecoster, Lynn-
item.contributorRutten, Annemie-
item.contributorSchreuer, Max-
item.contributorLoontiens, Siebe-
item.contributorvan der Meulen, Joni-
item.contributorMEBIS, Jeroen-
item.contributorCUPPENS, Kristof-
item.contributorTejpar, Sabine-
item.contributorVanden Bempt, Isabelle-
item.contributorDe Greve, Jacques-
item.contributorSchroeder, David-
item.contributorvan Marcke, Cedric-
item.contributorvan den Bulcke, Marc-
item.contributorde Azambuja, Evandro-
item.contributorPunie, Kevin-
item.contributorMAES, Brigitte-
item.fullcitationVOLDERS, Pieter-Jan; Aftimos, Philippe; Dedeurwaerdere, Franceska; Martens, Geert; Canon, Jean-Luc; Beniuga, Gabriela; Van Huysse, Jacques; FROYEN, Guy; De Pauw, Rebecca; Prenen, Hans; Lambin, Suzan; Decoster, Lore; Vaeyens, Freya; Rottey, Sylvie; Van Dam, Pieter-Jan; Decoster, Lynn; Rutten, Annemie; Schreuer, Max; Loontiens, Siebe; van der Meulen, Joni; MEBIS, Jeroen; CUPPENS, Kristof; Tejpar, Sabine; Vanden Bempt, Isabelle; De Greve, Jacques; Schroeder, David; van Marcke, Cedric; van den Bulcke, Marc; de Azambuja, Evandro; Punie, Kevin & MAES, Brigitte (2025) A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer. In: Npj Precision Oncology, 9 (1) (Art N° 66).-
item.accessRightsOpen Access-
crisitem.journal.eissn2397-768X-
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