Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/45805

Title:	Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease
Authors:	Windster, Jonathan D Kakiailatu, Naomi J M Kuil, Laura E Antanaviciute, Agne Sacchetti, Andrea MacKenzie, Katherine C Peulen-Zink, Joke Kan, Tsung W Bindels, Eric de Pater, Emma Doukas, Michael van den Bosch, Thierry P P Yousefi, Soheil Barakat, Tahsin-Stefan Meeussen, Conny J H M Sloots, Pim C E J Wijnen, Renee M H Parikh, Kaushal BOESMANS, Werend Melotte , Veerle Hofstra, Robert M W Simmons, Alison Alves, Maria M
Issue Date:	2024
Source:	Gastroenterology,
Status:	In press
Abstract:	The enteric nervous system (ENS), which is composed of neurons and glia, regulates intestinal motility. Hirschsprung disease (HSCR) results from defects in ENS formation; however, although neuronal aspects have been studied extensively, enteric glia remain disregarded. This study aimed to explore enteric glia diversity in health and disease.
Keywords:	ENS;Enteric Glia;Hirschsprung Disease;Prucalopride;Schwann Cells;Single-Cell RNA Sequencing
Document URI:	http://hdl.handle.net/1942/45805
DOI:	10.1053/j.gastro.2024.12.011
ISI #:	001492939400001
Rights:	© 2025 The Author(s). Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
Category:	A2
Type:	Journal Contribution
Appears in Collections:	Research publications

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