Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/46269
Title: The temporal relationship between body composition and cardiometabolic profiles in an HIV-infected (on antiretroviral therapy) versus HIV-free Western Cape study population
Authors: Dinnie, Y
EVERSON, Frans 
Kamau, FM
Webster, I
Kgokane, B
DE BOEVER, Patrick 
Goswami, N
Strijdom, H
Issue Date: 2024
Publisher: CLINICS CARDIVE PUBL PTY LTD
Source: Cardiovascular Journal of Africa, 35 (4) , p. 416 -424
Abstract: Cardiovascular risk is a health concern in people living with HIV/AIDS (PLWH). This longitudinal study (baseline vs 36 months) aimed to investigate the relationship between body composition and markers of cardiovascular risk in a South African study population [HIV free, n = 22 vs HIV positive on antiretroviral therapy (HIV+ART), n = 73)]. Health questionnaires, anthropometric measurements, biochemical analyses and flow-mediated dilation were performed. Linear mixed-model statistical analyses were applied. The HIV+ART vs the HIV-free groups were independently associated with body mass index (BMI) [-4.92 (-7.99 to -1.84), p = 0.002] and waist circumference [-10.5 (-17.2 to -3.77), p = 0.003]. ART duration was associated with BMI [2.60 (0.57-4.62), p = 0.013], waist circumference [3.83 (0.03-7.63), p = 0.048] and high-density lipoprotein cholesterol [20.18 (2.37-41.09), p = 0.025]. The data showed that intricate relationships existed in this study population between HIV, ART, body composition and cardiometabolic variables. There is a need for more research investigating cardiovascular risk in PLWH, particularly in the context of changes in body composition measures.
Keywords: body composition;body mass index;waist circumfer- ence;HIV/AIDS;cardiovascular risk;antiretroviral therapy
Document URI: http://hdl.handle.net/1942/46269
ISSN: 1995-1892
e-ISSN: 1680-0745
DOI: 10.5830/CVJA-2024-005
ISI #: 001198371900001
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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