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http://hdl.handle.net/1942/463
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DC Field | Value | Language |
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dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | GEYS, Helena | - |
dc.contributor.author | RENARD, Didier | - |
dc.contributor.author | BURZYKOWSKI, Tomasz | - |
dc.date.accessioned | 2004-11-04T09:10:04Z | - |
dc.date.available | 2004-11-04T09:10:04Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Stasinopoulos, Mikis & Touloumi, Giota (Ed.) Proceedings of the 17th International Workshop on Statistical Modelling. p. 491-498. | - |
dc.identifier.uri | http://hdl.handle.net/1942/463 | - |
dc.description.abstract | The validation of surrogate endpoints has been studied by Prentice (1989). He presented a definition as well as a set of criteria that are equivalent if the surrogate and true endpoints are binary. Freedman (1992) supplemented these criteria with the so-called proportion explained. Buyse and Molenberghs (1998) proposed to replace the proportion explained by two quantities: (1) the relative effect linking the effect of treatment on both endpoints and (2) the adjusted association, an individual-level measure of agreement between both endpoints. In this paper, we argue that a meta-analytic approach should be adopted because it overcomes difficulties which necessarily surround validation efforts based on a single trial. | - |
dc.language.iso | en | - |
dc.subject | Clustered data | - |
dc.subject | Clinical trials | - |
dc.subject | Surrogate Markers | - |
dc.subject.other | adjusted Assocation; meta-analysis; proportion explained; random effects model; relative effect; surrogate endpoint; validation | - |
dc.title | Challenges in the methodology for the validation of surrogate endpoints in randomized trials | - |
dc.type | Proceedings Paper | - |
local.bibliographicCitation.authors | Stasinopoulos, Mikis | - |
local.bibliographicCitation.authors | Touloumi, Giota | - |
local.bibliographicCitation.conferencedate | 08-12/07/2002 | - |
local.bibliographicCitation.conferencename | Proceedings of the 17th International Workshop on Statistical Modelling | - |
local.bibliographicCitation.conferenceplace | Chania - Crete, Greece | - |
dc.identifier.epage | 498 | - |
dc.identifier.spage | 491 | - |
local.bibliographicCitation.jcat | C2 | - |
local.type.refereed | Refereed | - |
local.type.specified | Proceedings Paper | - |
dc.bibliographicCitation.oldjcat | C2 | - |
dc.identifier.url | http://www.statmod.org/files/proceedings/iwsm2002_proceedings.pdf | - |
local.bibliographicCitation.btitle | Proceedings of the 17th International Workshop on Statistical Modelling | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | MOLENBERGHS, Geert; BUYSE, Marc; GEYS, Helena; RENARD, Didier & BURZYKOWSKI, Tomasz (2002) Challenges in the methodology for the validation of surrogate endpoints in randomized trials. In: Stasinopoulos, Mikis & Touloumi, Giota (Ed.) Proceedings of the 17th International Workshop on Statistical Modelling. p. 491-498.. | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | BUYSE, Marc | - |
item.contributor | GEYS, Helena | - |
item.contributor | RENARD, Didier | - |
item.contributor | BURZYKOWSKI, Tomasz | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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iwsm2002_proceedings-500-507.pdf | Published version | 410.13 kB | Adobe PDF | View/Open |
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