Dietary alterations in gut microbiota impact anti-tumor immunity: towards novel strategies to boost cancer immunotherapy

Abstract

Introduction Dietary factors could profoundly shape host immunity and gut microbiota and disease. High salt intake has been shown to be detrimental in autoimmune conditions by directly affecting the immune cell balance or indirectly altering gut microbiota and metabolites. We have recently demonstrated that a high salt diet (HSD), could be beneficial in cancer by promoting enhanced antitumor immunity through modulation of myeloid-derived suppressor cell (MDSC) function.