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http://hdl.handle.net/1942/674
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DC Field | Value | Language |
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dc.contributor.author | ALONSO ABAD, Ariel | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | BURZYKOWSKI, Tomasz | - |
dc.contributor.author | RENARD, Didier | - |
dc.contributor.author | GEYS, Helena | - |
dc.contributor.author | SHKEDY, Ziv | - |
dc.contributor.author | TIBALDI, Fabian | - |
dc.contributor.author | CORTINAS ABRAHANTES, Jose | - |
dc.contributor.author | BUYSE, Marc | - |
dc.date.accessioned | 2005-03-18T14:56:47Z | - |
dc.date.available | 2005-03-18T14:56:47Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Biometrics, 60(3). p. 724-728 | - |
dc.identifier.uri | http://hdl.handle.net/1942/674 | - |
dc.description.abstract | We put a perspective on the strengths and limitations of statistical methods for the evaluation of surrogate endpoints. Whereas using several trials overcomes some of the limitations of a single-trial framework (Prentice, 1989, Statistics in Medicine8, 431–440), arguably the evaluation of surrogate endpoints can never be done using only statistical evidence but such evidence should be seen as but one component in a decision-making process that involves, among others, a number of clinical and biological considerations. We briefly present a hierarchical framework that incorporates ideas from Prentice's work and is uniformly applicable to different types of surrogate and true clinical outcomes | - |
dc.format.extent | 119908 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | - |
dc.subject | Surrogate Markers | - |
dc.subject | Longitudinal data | - |
dc.subject | Clinical trials | - |
dc.subject.other | hierarchical model; likelihood reduction factor; prentice criteria; surrogate endpoints | - |
dc.title | Prentice's approach and the meta-analytic paradigm: a reflection on the role of statistics in the evaluation of surrogate endpoints | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 728 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 724 | - |
dc.identifier.volume | 60 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1111/j.0006-341X.2004.00222.x | - |
dc.identifier.isi | 000223818200022 | - |
item.validation | ecoom 2005 | - |
item.contributor | ALONSO ABAD, Ariel | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | BURZYKOWSKI, Tomasz | - |
item.contributor | RENARD, Didier | - |
item.contributor | GEYS, Helena | - |
item.contributor | SHKEDY, Ziv | - |
item.contributor | TIBALDI, Fabian | - |
item.contributor | CORTINAS ABRAHANTES, Jose | - |
item.contributor | BUYSE, Marc | - |
item.accessRights | Open Access | - |
item.fullcitation | ALONSO ABAD, Ariel; MOLENBERGHS, Geert; BURZYKOWSKI, Tomasz; RENARD, Didier; GEYS, Helena; SHKEDY, Ziv; TIBALDI, Fabian; CORTINAS ABRAHANTES, Jose & BUYSE, Marc (2004) Prentice's approach and the meta-analytic paradigm: a reflection on the role of statistics in the evaluation of surrogate endpoints. In: Biometrics, 60(3). p. 724-728. | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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burt14.pdf | Published version | 117.1 kB | Adobe PDF | View/Open |
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