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Title: | Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model | Authors: | Vloeberghs, Ellen Van Dam, Debby Franck, Frieda Staufenbiel, Matthias SERROYEN, Jan MOLENBERGHS, Geert De Deyn, Peter Paul |
Issue Date: | 2008 | Publisher: | AMER PSYCHOLOGICAL ASSOC | Source: | BEHAVIORAL NEUROSCIENCE, 122(3). p. 491-497 | Abstract: | Transgenic APP23 mice were generated to model Alzheimer's disease. The APP23 model develops pathological features, learning deficits, and memory deficits analogous to dementing patients. In this report, transgenic mice exhibited several behavioral disturbances indicating the presence of neuropsychiatric symptoms of dementia. Aiming to verify whether the model also develops other behavioral problems, the authors investigated ingestive behavior in APP23 males of 3, 6 and 12 months. In addition, body weights of a naive male group were longitudinally monitored starting at weaning. Olfactory acuity was evaluated in mice of different age groups. Although olfactory functioning of APP23 mice appeared intact, they drank more and took more food pellets compared with wild-type littermates during a 1-week registration period. From the age of 4.5 weeks onward, APP23 males weighed significantly less than their control littermates, whereas this difference became more prominent with increasing age. Our results suggest the presence of a hypermetabolic state in this model. This is the first report, evidencing the presence of changes in eating and drinking behavior in a single transgenic Alzheimer mouse model. | Notes: | Univ Antwerp, Dept Biomed Sci, Inst Born Bunge, Lab Neurochem & Behav, B-2610 Antwerp, Belgium. Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. Novartis Inst Biomed Res Basel, Basel, Switzerland. Middleheim Gen Hosp, Memory Clin, Dept Neurol, Antwerp, Belgium. | Keywords: | Alzheimer's disease; transgenic mice; ingestive behavior; growth; olfaction;Alzheimer's disease; transgenic mice; ingestive behavior; growth; olfaction | Document URI: | http://hdl.handle.net/1942/8328 | ISSN: | 0735-7044 | e-ISSN: | 1939-0084 | DOI: | 10.1037/0735-7044.122.3.491 | ISI #: | 000256210300001 | Rights: | Copyright 2008 by the American Psychological Association | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2009 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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GeertMolenberghs6.pdf | Peer-reviewed author version | 260.78 kB | Adobe PDF | View/Open |
vloeberghs2008.pdf Restricted Access | Published version | 339.34 kB | Adobe PDF | View/Open Request a copy |
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