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http://hdl.handle.net/1942/9753
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.date.accessioned | 2009-08-19T07:28:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | DRUG INFORMATION JOURNAL, 43(4). p. 409-429 | - |
dc.identifier.issn | 0092-8615 | - |
dc.identifier.uri | http://hdl.handle.net/1942/9753 | - |
dc.description.abstract | Statistical analysis often extends beyond the data available. This is especially true when data are incompletely recorded because ad hoc as well as model-based approaches are rooted not only in the observed data and the mechanism governing missingness, but also in the unobserved given the observed data. Other instances of this phenomenon include but are not limited to censored time-to-event data, random effects models, and latent class approaches. One needs to be aware of (1) changes in results and intuition relative to complete-data analysis; (2) the assumptions under which such approaches are valid; (3) the sensitivities implied by departures; and (4) in response to these, what sensitivity analysis avenues are available. This article provides a bird's-eye perspective on these. Some of the developments are illustrated using data from a clinical trial in onychomycosis. | - |
dc.format.extent | 429284 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | DRUG INFORMATION ASSOC | - |
dc.rights | (c) 2009 Drug Information Association Inc. | - |
dc.subject.other | Linear mixed model; Missing at random; Missing completely at random; Non-future dependence; Pattern-mixture model; Selection model; Shared-parameter model | - |
dc.subject.other | linear mixed model; missing at random; missing completely at random; non-future dependence; pattern-mixture model; selection model; shared-parameter model | - |
dc.title | Incomplete Data in Clinical Studies: Analysis, Sensitivity, and Sensitivity Analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 429 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 409 | - |
dc.identifier.volume | 43 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Univ Hasselt, Ctr Stat, B-3590 Diepenbeek, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | 000267877500004 | - |
item.fullcitation | MOLENBERGHS, Geert (2009) Incomplete Data in Clinical Studies: Analysis, Sensitivity, and Sensitivity Analysis. In: DRUG INFORMATION JOURNAL, 43(4). p. 409-429. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2010 | - |
item.contributor | MOLENBERGHS, Geert | - |
crisitem.journal.issn | 0092-8615 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
dijmiss02.pdf | Peer-reviewed author version | 429.43 kB | Adobe PDF | View/Open |
out (3).pdf Restricted Access | Published version | 1.61 MB | Adobe PDF | View/Open Request a copy |
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