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http://hdl.handle.net/1942/9833
Title: | Diamond-based DNA sensors: surface functionalization and read-out strategies | Authors: | WENMACKERS, Sylvia VERMEEREN, Veronique VAN DE VEN, Martin AMELOOT, Marcel BIJNENS, Nathalie HAENEN, Ken MICHIELS, Luc WAGNER, Patrick |
Issue Date: | 2009 | Publisher: | WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY | Source: | PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 206(3). p. 391-408 | Abstract: | This article reviews the Current state-of-the art of diamond-based DNA sensors. Some general concepts involved in biosensors are introduced and applied to DNA sensors. The properties of chemically vapor deposited (CVD) diamond relevant for this application are summed up, with special attention for the stability and bio-compatibility of the material. Several routes to functionalize the diamond Surface are considered. The physical properties of the obtained DNA layers are discussed in terms of surface density and molecular conformation. Possible read-out strategies are evaluated, including optical and electronic sensing. With diamond-based DNA sensors, real-time and label-free sensing is achieved. | Notes: | Feature Article | Keywords: | FIELD-EFFECT TRANSISTORS; LABEL-FREE DETECTION; ATOMIC-FORCE MICROSCOPE; VAPOR-DEPOSITED DIAMOND; BORON-DOPED DIAMOND; SINGLE-STRANDED-DNA; OF-THE-ART; THIN-FILMS; CVD-DIAMOND; PHOTOCHEMICAL FUNCTIONALIZATION | Document URI: | http://hdl.handle.net/1942/9833 | ISSN: | 1862-6300 | e-ISSN: | 1862-6319 | DOI: | 10.1002/pssa.200880486 | ISI #: | 000264691800002 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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haenen2.pdf | Published version | 1.08 MB | Adobe PDF | View/Open |
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