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Title: | Evaluation of Molecular Assays for Rapid Detection of Methicillin-Resistant Staphylococcus aureus | Authors: | Malhotra-Kumar, Surbhi Van Heirstraeten, Liesbet Lee, Andie CORTINAS ABRAHANTES, Jose Lammens, Christine Vanhommerig, Evelyn MOLENBERGHS, Geert AERTS, Marc Harbarth, Stephan Goossens, Herman |
Issue Date: | 2010 | Publisher: | AMER SOC MICROBIOLOGY | Source: | JOURNAL OF CLINICAL MICROBIOLOGY, 48(12). p. 4598-4601 | Abstract: | The diagnostic sensitivities of the BD GeneOhm and Cepheid Xpert assays were compared using culture on log-serial dilutions of well-characterized methicillin-resistant Staphylococcus aureus (MRSA) and non-MRSA strains and on nasal and groin swabs from patients with histories of MRSA carriage. The sensitivities of GeneOhm and Xpert were high at 10(3)-CFU/ml MRSA concentrations (92.3% and 96.3%, respectively) although decreased considerably (< 35%) at a 1-log-lower concentration. Unexpectedly, both assays also detected select coagulase-negative staphylococci, which requires further evaluation. | Notes: | [Malhotra-Kumar, Surbhi; Van Heirstraeten, Liesbet; Lammens, Christine; Vanhommerig, Evelyn; Goossens, Herman] Univ Antwerp, Dept Med Microbiol, Antwerp, Belgium. [Malhotra-Kumar, Surbhi; Van Heirstraeten, Liesbet; Lammens, Christine; Vanhommerig, Evelyn; Goossens, Herman] Univ Antwerp, Vaccine & Infect Dis Inst, Antwerp, Belgium. [Lee, Andie; Harbarth, Stephan] Univ Hosp Geneva, Geneva, Switzerland. [Lee, Andie; Harbarth, Stephan] Univ Geneva, Sch Med, CH-1211 Geneva, Switzerland. [Abrahantes, Jose Cortinas; Molenberghs, Geert; Aerts, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. | Document URI: | http://hdl.handle.net/1942/11380 | ISSN: | 0095-1137 | e-ISSN: | 1098-660X | DOI: | 10.1128/JCM.00004-10 | ISI #: | 000284693400042 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2011 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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TMP-03191-10_1.pdf | Peer-reviewed author version | 73.7 kB | Adobe PDF | View/Open |
a.pdf | Published version | 52.78 kB | Adobe PDF | View/Open |
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