Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12876
Title: An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis
Authors: KICINSKI, Michal 
VANGRONSVELD, Jaco 
NAWROT, Tim 
Issue Date: 2011
Publisher: PUBLIC LIBRARY SCIENCE
Source: PLOS ONE, 6(10)
Abstract: Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI: 2.37-4.15), and for those with affected father 2.35 times (CI: 2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI: 2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR: 2.87, CI: 2.21-3.74), than in men aged 65 and older (RR: 1.92, CI: 1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI: 55.6-63.5%) for men at all ages, 65.2% (CI: 57.7-71.4%) for men younger than 65 and 47.9% (CI: 37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI: 65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).
Notes: [Kicinski, Michal] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ KULeuven, Dept Publ Hlth, Louvain, Belgium. michal.kicinski@uhasselt.be
Keywords: Biology; 5 genetic-variants; nationwide register cohort; population-based cohort; african-american men; risk-factors; breast-cancer; history; carcinoma; database
Document URI: http://hdl.handle.net/1942/12876
ISSN: 1932-6203
e-ISSN: 1932-6203
DOI: 10.1371/journal.pone.0027130
ISI #: 000296916000056
Rights: © 2011 Kiciński et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Category: A1
Type: Journal Contribution
Validations: ecoom 2012
Appears in Collections:Research publications

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