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Title: The effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo
Authors: SMETS, Anke 
Nuydens, R.
DE JONGH, Rafael 
Pintelon, I.
THYS, Isabel 
Timmermans, J. P.
RIGO, Jean-Michel 
MEERT, Theo 
Issue Date: 2009
Publisher: MEDIMOND S R L
Source: Baron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156
Abstract: The high levels of histamine in brain after traumatic brain injury and the observed influence of histamine on aquaporin-1 (AQP-1) localization in gastric cells, lead to the hypothesis that histamine could play a major role in the pathophysiology of brain edema An intracerebroventricular (ICV) histamine induced brain edema model was developed in rats. Infusion of concentrations >= 50 mM histamine resulted in a dose-dependent intracranial pressure (ICP) increase and death. Furthermore, histological experiments showed the internalization of membrane-expressed AQP4 after histamine challenge. The decreased fraction of functional membrane-associated AQP4 might result in an increased intracranial p[ressure. In this new experimental rat mode, the functional activity of novel treatment options for increased ICP, IV or ICV administration, can readily be tested.
Notes: Address: Smets, A (reprint author), Univ Hasselt, Biomed Res Unit BIOMED, Diepenbeek, Belgium.
Keywords: Clinical Neurology; Neurosciences
Document URI:
ISBN: 978-88-7587-521-3
ISI #: 000292191900030
Category: C1
Type: Proceedings Paper
Validations: ecoom 2012
Appears in Collections:Research publications

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