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Title: | Comparison of methods for the selection of genomic biomarkers | Authors: | LIN, Dan Tilahun, Abel Abrahantes, Jose Cortinas SHKEDY, Ziv MOLENBERGHS, Geert Gohlmann, Hinrich W. H. TALLOEN, Willem BIJNENS, Luc |
Issue Date: | 2013 | Publisher: | INDERSCIENCE ENTERPRISES LTD | Source: | INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS, 8 (1), p. 24-41 | Abstract: | In recent years, a lot of attention is placed on the selection and evaluation of biomarkers in microarray experiments. Two sets of biomarkers are of importance, namely therapeutic and prognostic. The therapeutic biomarkers would give us information on the response of the genes to treatment in relation to the response of the clinical outcome to the same treatments, whereas the prognostic biomarkers enable us to predict the clinical outcome irrespective of treatments and other confounding factors. In this paper, we use different methods that allow for both linear and non-linear associations to select prognostic markers for depression, the response. | Notes: | Univ Hasselt, I Biostat, B-3590 Diepenbeek, Belgium. Harvard Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02138 USA. European Food Safety Author, Sci Assessment Support Unit, I-43100 Parma, Italy. Katholieke Univ Leuven, B-3000 Louvain, Belgium. Janssen Pharmaceut Co Johnson & Johnson, B-2340 Beerse, Belgium. | Keywords: | prognostics biomarkers; microarray experiments; linear associations; non-linear associations;prognostics biomarkers; microarray experiments; linear associations; non-linear associations | Document URI: | http://hdl.handle.net/1942/15408 | ISSN: | 1748-5673 | e-ISSN: | 1748-5681 | DOI: | 10.1504/IJDMB.2013.054691 | ISI #: | 000320772900002 | Rights: | © 2013 Inderscience Enterprises Ltd. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
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BiomarkerIJDMB.pdf Restricted Access | Peer-reviewed author version | 255.59 kB | Adobe PDF | View/Open Request a copy |
lin2013.pdf Restricted Access | Published version | 1.09 MB | Adobe PDF | View/Open Request a copy |
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