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http://hdl.handle.net/1942/15482
Title: | Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice | Authors: | BIESMANS, Steven MEERT, Theo Bouwknecht, Jan A. Acton, Paul D. DAVOODI, Nima De Haes, Patrick KUIJLAARS, Jacobine Langlois, Xavier Matthews, Liam J. R. Donck, Luc Ver HELLINGS, Niels Nuydens, Rony |
Issue Date: | 2013 | Publisher: | HINDAWI PUBLISHING CORPORATION | Source: | MEDIATORS OF INFLAMMATION, 2013, (ART N° 271359) | Abstract: | Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model. | Notes: | [Biesmans, Steven; Meert, Theo F.; Davoodi, Nima; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Meert, Theo F.; Bouwknecht, Jan A.; Davoodi, Nima; De Haes, Patrick; Kuijlaars, Jacobine; Langlois, Xavier; Matthews, Liam J. R.; Donck, Luc Ver; Nuydens, Rony] Janssen Res & Dev, Div Janssen Pharmaceut NV, Neurosci, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA. | Keywords: | Cell Biology; Immunology | Document URI: | http://hdl.handle.net/1942/15482 | ISSN: | 0962-9351 | e-ISSN: | 1466-1861 | DOI: | 10.1155/2013/271359 | ISI #: | 000322395400001 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
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biesmans 1.pdf | Published version | 2.03 MB | Adobe PDF | View/Open |
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