Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/16472
Title: | Exercise-onset heart rate increase is slowed in multiple sclerosis patients: does a disturbed cardiac autonomic control affect exercise tolerance? | Authors: | HANSEN, Dominique WENS, Inez DENDALE, Paul OP 'T EIJNDE, Bert |
Issue Date: | 2013 | Source: | NEUROREHABILITATION, 33 (1), p. 139-146 | Abstract: | OBJECTIVE:To explore the etiology of exercise intolerance in patients with MS, it is analyzed whether a disturbed cardiac autonomic control could be observed during exercise testing in patients with MS, and is related to exercise tolerance. PATIENTS AND METHOD:From 26 MS patients and 15 healthy subjects, exercise-onset (first 20 and 60 seconds) and –offset (1-minute recovery) HR change was determined during a 6-minute constant-load exercise bout on bike. Blood lactate, HR, oxygen uptake, expiratory volume and perceived exertion were assessed during exercise, and compared between groups. In 15 MS patients, a 6-min walking test was executed. RESULT:Twenty-second exercise-onset HR increase was significantly smaller in MS patients (14±7 bts/min) vs. healthy subjects (20±8 bts/min,p< 0.05), and independently related to MS and age in total group (p< 0.05). Sixty-second exercise-onset and –offset HR changes were not different between groups, nor independently related to MS presence (p> 0.05). A significant correlation was found between 20-second exercise-onset HR increase and walking capacity in MS patients (r= 0.64,p< 0.01). CONCLUSION:In MS patients, the early increase in heart rate during endurance exercise is significantly slowed, indicating a disturbed cardiac autonomic control, and is related to exercise tolerance. | Keywords: | multiple sclerosis; endurance exercise; exercise testing; heart rate; autonomic control | Document URI: | http://hdl.handle.net/1942/16472 | ISSN: | 1053-8135 | e-ISSN: | 1878-6448 | DOI: | 10.3233/NRE-130938 | ISI #: | 000324260400018 | Rights: | © 2013 – IOS Press and the authors. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Neurorehabilitation 2013.pdf Restricted Access | 193.81 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
11
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
17
checked on Oct 13, 2024
Page view(s)
138
checked on Apr 26, 2023
Download(s)
112
checked on Apr 26, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.