Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16472
Title: Exercise-onset heart rate increase is slowed in multiple sclerosis patients: does a disturbed cardiac autonomic control affect exercise tolerance?
Authors: HANSEN, Dominique 
WENS, Inez 
DENDALE, Paul 
OP 'T EIJNDE, Bert 
Issue Date: 2013
Source: NEUROREHABILITATION, 33 (1), p. 139-146
Abstract: OBJECTIVE:To explore the etiology of exercise intolerance in patients with MS, it is analyzed whether a disturbed cardiac autonomic control could be observed during exercise testing in patients with MS, and is related to exercise tolerance. PATIENTS AND METHOD:From 26 MS patients and 15 healthy subjects, exercise-onset (first 20 and 60 seconds) and –offset (1-minute recovery) HR change was determined during a 6-minute constant-load exercise bout on bike. Blood lactate, HR, oxygen uptake, expiratory volume and perceived exertion were assessed during exercise, and compared between groups. In 15 MS patients, a 6-min walking test was executed. RESULT:Twenty-second exercise-onset HR increase was significantly smaller in MS patients (14±7 bts/min) vs. healthy subjects (20±8 bts/min,p< 0.05), and independently related to MS and age in total group (p< 0.05). Sixty-second exercise-onset and –offset HR changes were not different between groups, nor independently related to MS presence (p> 0.05). A significant correlation was found between 20-second exercise-onset HR increase and walking capacity in MS patients (r= 0.64,p< 0.01). CONCLUSION:In MS patients, the early increase in heart rate during endurance exercise is significantly slowed, indicating a disturbed cardiac autonomic control, and is related to exercise tolerance.
Keywords: multiple sclerosis; endurance exercise; exercise testing; heart rate; autonomic control
Document URI: http://hdl.handle.net/1942/16472
ISSN: 1053-8135
e-ISSN: 1878-6448
DOI: 10.3233/NRE-130938
ISI #: 000324260400018
Rights: © 2013 – IOS Press and the authors. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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