Please use this identifier to cite or link to this item:
Title: Mandatory oral glucose tolerance tests identify more diabetics in stable patients with chronic heart failure: a prospective observational study.
Authors: STEVENS, An 
HANSEN, Dominique 
Vandoren, Vincent
Westerlaken, Rob
Issue Date: 2014
Source: Diabetology & Metabolic Syndrome, 6(1), (ART N° 44)
Abstract: BACKGROUND: Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal muscle strength. METHODS: A prospective observational study was set up. Inclusion criteria were diagnosis of CHF, stable condition and absence of glucose-lowering medication. Patients underwent a 2 h oral glucose tolerance test (OGTT), isometric strength testing of the upper leg and dual energy x-ray absorptiometry. Health-related quality of life and physical activity level were assessed by questionnaire. RESULTS: Data of 56 participants were analyzed. Despite near-normal fasting glucose values, 55% was classified as prediabetic, 14% as diabetic, and 20% as normal glucose tolerant. Of all newly diagnosed diabetic patients, 79% were diagnosed because of 2 h glucose values only and none because of HbA1c. Univariate mixed model analysis revealed ischaemic aetiology, daily physical activity, E/E', fat trunk/fat limbs and extension strength as possible explanatory variables for the glucose curve during the glucose tolerance test. When combined in one model, only fat trunk/fat limbs and E/E' remained significant predictors. Furthermore, fasting insulin was correlated with fat mass/height2 (r = 0.51, p < 0.0001), extension strength (r = -0.33, p < 0.01) and triglycerides (r = 0.39, p < 0.01). CONCLUSIONS: Our data confirm that a large majority of CHF patients have impaired glucose tolerance. This glucose intolerance is related to fat distribution and left ventricular end-diastolic pressure.
Notes: Stevens, ALM (reprint author), Hasselt Univ, REVAL Rehabil Res Ctr, Martelarenlaan 42, BE-3500 Hasselt, Belgium,
Keywords: insulin resistance; body composition; muscle strength; quality of life
Document URI:
e-ISSN: 1758-5996
DOI: 10.1186/1758-5996-6-44
ISI #: 000334617500001
Rights: © 2014 Stevens et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
stevens et al. Diabetol Metabol Syndr 2014.pdfpublished version166.55 kBAdobe PDFView/Open
Show full item record


checked on Sep 3, 2020


checked on May 21, 2022

Page view(s)

checked on May 22, 2022


checked on May 22, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.