Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17231
Title: Efficient [2+2] photocycloadditions under equimolar conditions by employing a continuous UV-flow reactor
Authors: CONRADI, Matthias Horst 
JUNKERS, Tanja 
Issue Date: 2013
Publisher: ELSEVIER SCIENCE SA
Source: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 259, p. 41-46
Abstract: The [2 + 2] photocycloaddition between maleimide and various alkenes was optimized in a simple custom-made UV flow reactor. While complete maleimide conversion is only achieved with excesses of at least 10 eq. of alkene and reaction times of 12-24 h in batch, complete reactions with yields in the range >98% could be obtained in 5 min in the flow reactor under strictly equimolar conditions. Functional alkenes carrying allyl, alcohol, amine and ether moieties were successfully conjugated in good yields under optimized reaction conditions. As is demonstrated, the reaction gains in flow most characteristics of a high-efficient reaction, making the process highly valuable for upscaled synthesis of maleimide conjugates. (C) 2013 Elsevier B.V. All rights reserved.
Notes: [Conradi, Matthias; Junkers, Thomas] Univ Hassel, Inst Mat Res, Polymer React Design Grp, IMO, B-3590 Diepenbeek, Belgium.
Keywords: [2 + 2]-cycloaddition; photochemistry; flow chemistry; functional group tolerance; photo-conjugation;[2+2]-Cycloaddition; Photochemistry; Flow chemistry; Functional group tolerance; photo-conjugation
Document URI: http://hdl.handle.net/1942/17231
ISSN: 1010-6030
e-ISSN: 1873-2666
DOI: 10.1016/j.jphotochem.2013.02.024
ISI #: 000319089900006
Rights: © 2013 Elsevier B.V. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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