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http://hdl.handle.net/1942/20614
Title: | Impact of High Intensity Exercise on Muscle Morphology in EAE Rats | Authors: | WENS, Inez Dalgas, U. VERBOVEN, Kenneth Kosten, L. STEVENS, An HENS, Niel OP 'T EIJNDE, Bert |
Issue Date: | 2015 | Publisher: | ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY | Source: | PHYSIOLOGICAL RESEARCH, 64 (6), p. 907-923 | Abstract: | The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak work during isokinetic muscle performance in EAE-animals. However, exercise was not able to prevent muscle fiber atrophy. | Notes: | [Wens, I.; Verboven, K.; Kosten, L.; Stevens, A.; Eijnde, B. O.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Dalgas, U.] Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Aarhus, Denmark. [Hens, N.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, N.] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modelling Infect Dis, B-2020 Antwerp, Belgium. | Keywords: | EAE; muscle strength; muscle fiber characteristics; high intensity treadmill running; BDNF;EAE; Muscle strength; Muscle fiber characteristics; High intensity treadmill running; BDNF | Document URI: | http://hdl.handle.net/1942/20614 | ISSN: | 0862-8408 | e-ISSN: | 1802-9973 | ISI #: | 000367547900013 | Rights: | © 2015 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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