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http://hdl.handle.net/1942/21517
Title: | Clinical benefit of atrio-ventricular delay optimization in patients with a dual-chamber pacemaker: a pilot study The CBRAVO trial (NCT01998256) | Authors: | Cools, Thijs Daerden, Tara HERBOTS, Lieven Geukens, Robert VERWERFT, Jan KOOPMAN, Pieter Dilling-Boer, Dagmara HANSEN, Dominique VRANCKX, Pascal DENDALE, Paul |
Issue Date: | 2016 | Source: | ACTA CARDIOLOGICA, 71 (3), p. 257-265 | Abstract: | Objective: Outcome data on exercise capacity following atrio-ventricular (AV) optimization of dual-chamber pacing are sparse. Pacemaker settings are often left at manufacturers’ nominal values upon implantation. We studied the short-term effect of AV optimization on exercise capacity in patients with a dual-chamber pacemaker. Methods and results: Twenty-eight patients (mean age 73 ± 14 y) with a dual-chamber pacemaker, were randomized towards either nominal AV settings (group 1) or echo-guided AV optimization using the iterative mitral inflow VTI (velocity time integral) method (group 2) at baseline. At 4 weeks, patients were crossed-over to AV optimization in group 1 and returned to nominal AV settings in group 2 for another period of 4 weeks. Oxygen uptake efficiency slope improved significantly after AV optimization (by 126.7 mL/logL ± 190.7 mL/logL; P = 0.003). Conclusions: AV optimization in dual-chamber pacing significantly improved functional capacity after 4 weeks. These data provide the background for further validation studies. | Notes: | Cools, T (reprint author), Jessa Hosp, Stadsomvaart 11, B-3500 Hasselt, Belgium thijs.cools@gmail.com | Document URI: | http://hdl.handle.net/1942/21517 | ISSN: | 0001-5385 | e-ISSN: | 1784-973X | DOI: | 10.2143/AC.71.3.3152085 | ISI #: | 000378444700002 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Cools et al. Acta Cardiol 2016.pdf | Published version | 2.67 MB | Adobe PDF | View/Open |
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