Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21803
Title: Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury
Authors: GEURTS, Nathalie 
VANGANSEWINKEL, Tim 
LEMMENS, Stefanie 
NELISSEN, Sofie 
GEBOES, Lies 
Schwartz, Christian
Voehringer, David
HENDRIX, Sven 
Issue Date: 2016
Publisher: FEDERATION AMER SOC EXP BIOL
Source: JOURNAL OF LEUKOCYTE BIOLOGY, 99 (4), p. 579-582
Abstract: Basophils are the smallest population of granulocytes found in the circulation. They have crucial and non-redundant roles in allergic disorders, in protection from parasite infections, in autoimmunity, and in the regulation of type 2 immunity. They share phenotypic and functional properties with mast cells, which exert substantial protective effects after traumatic brain injury and spinal cord injury, although they are considered one of the most proinflammatory cell types in the body. In contrast, the in vivo functions of basophils in central nervous system trauma are still obscure and not well studied. In this study, we show that by comparing spinal cord injury in wild type vs. basophil-deficient Mcpt8Cre transgenic mice, the locomotor recovery is not affected in mice depleted in basophils. In addition, no substantial differences were observed in the lesion size and in the astrocytic and macrophage/microglia reaction between both mouse strains. Hence, despite the multiple properties shared with mast cells, these data show, for the first time, to our knowledge, that basophils are dispensable for the functional recovery process after hemisection injury to the spinal cord in mice.
Notes: [Geurts, Nathalie; Vangansewinkel, Tim; Lemmens, Stefanie; Nelissen, Sofie; Geboes, Lies; Hendrix, Sven] Hasselt Univ, Dept Morphol, Biomed Res Inst, Diepenbeek, Belgium. [Nelissen, Sofie] Hasselt Univ, Dept Cell Physiol, Biomed Res Inst, Diepenbeek, Belgium. [Schwartz, Christian; Voehringer, David] Univ Clin Erlangen, Dept Infect Biol, Inst Clin Microbiol Immunol & Hyg, Erlangen, Germany. [Schwartz, Christian] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany.
Keywords: mast cells; central nervous system damage; basso mouse scale; Mcpt8Cre
Document URI: http://hdl.handle.net/1942/21803
ISSN: 0741-5400
e-ISSN: 1938-3673
DOI: 10.1189/jlb.3AB0815-370R
ISI #: 000371891100009
Rights: © Society for Leukocyte Biology
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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