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Title: | Protein complex analysis: From raw protein lists to protein interaction networks | Authors: | Meysman, Pieter Titeca, Kevin Eyckerman, Sven Tavernier, Jan GOETHALS, Bart Martens, Lennart VALKENBORG, Dirk Laukens, Kris |
Issue Date: | 2015 | Source: | MASS SPECTROMETRY REVIEWS, 36 (5), p. 600-614 | Status: | In press | Abstract: | The elucidation of molecular interaction networks is one of the pivotal challenges in the study of biology. Affinity purification—mass spectrometry and other co-complex methods have become widely employed experimental techniques to identify protein complexes. These techniques typically suffer from a high number of false negatives and false positive contaminants due to technical shortcomings and purification biases. To support a diverse range of experimental designs and approaches, a large number of computational methods have been proposed to filter, infer and validate protein interaction networks from experimental pull-down MS data. Nevertheless, this expansion of available methods complicates the selection of the most optimal ones to support systems biology-driven knowledge extraction. In this review, we give an overview of the most commonly used computational methods to process and interpret co-complex results, and we discuss the issues and unsolved problems that still exist within the field | Notes: | Meysman, P (reprint author), Univ Antwerp, Dept Math & Comp Sci, ADReM, Middelheimlaan 1, Antwerp, Belgium. pieter.meysman@uantwerpen.be | Keywords: | bioinformatics; co-complex purification; protein–protein interaction networks | Document URI: | http://hdl.handle.net/1942/22782 | ISSN: | 0277-7037 | e-ISSN: | 1098-2787 | DOI: | 10.1002/mas.21485 | ISI #: | 000407931000003 | Rights: | © 2015 Wiley Periodicals, Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Meysman-2015-Mass Spectormetry Reviews-Protein complex analysis.pdf | Peer-reviewed author version | 399.46 kB | Adobe PDF | View/Open |
Meysman_et_al-2017-Mass_Spectrometry_Reviews.pdf Restricted Access | Published version | 451.64 kB | Adobe PDF | View/Open Request a copy |
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