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http://hdl.handle.net/1942/23064
Title: | Estimating the reliability of repeatedly measured endpoints based on linear mixed-effects models. A tutorial | Authors: | VAN DER ELST, Wim MOLENBERGHS, Geert Hilgers, Ralf-Dieter VERBEKE, Geert Heussen, Nicole |
Issue Date: | 2016 | Publisher: | WILEY-BLACKWELL | Source: | PHARMACEUTICAL STATISTICS, 15(6), p. 486-493 | Abstract: | There are various settings in which researchers are interested in the assessment of the correlation between repeated measurements that are taken within the same subject (i.e., reliability). For example, the same rating scale may be used to assess the symptom severity of the same patients by multiple physicians, or the same outcome may be measured repeatedly over time in the same patients. Reliability can be estimated in various ways, for example, using the classical Pearson correlation or the intra-class correlation in clustered data. However, contemporary data often have a complex structure that goes well beyond the restrictive assumptions that are needed with the more conventional methods to estimate reliability. In the current paper, we propose a general and flexible modeling approach that allows for the derivation of reliability estimates, standard errors, and confidence intervals - appropriately taking hierarchies and covariates in the data into account. Our methodology is developed for continuous outcomes together with covariates of an arbitrary type. The methodology is illustrated in a case study, and a Web Appendix is provided which details the computations using the R package CorrMixed and the SAS software. Copyright (c) 2016 John Wiley & Sons, Ltd. | Notes: | [Van der Elst, Wim; Molenberghs, Geert; Verbeke, Geert] Univ Hasselt, I BioStat, B-3590 Diepenbeek, Belgium. [Molenberghs, Geert; Verbeke, Geert] Katholieke Univ Leuven, I BioStat, Leuven, Belgium. [Hilgers, Ralf-Dieter; Heussen, Nicole] Rhein Westfal TH Aachen, Dept Med Stat, Aachen, Germany. | Keywords: | within-cluster correlation; test-retest reliability; intra-class correlation;within-cluster correlation; test-retest reliability; intra-class correlation | Document URI: | http://hdl.handle.net/1942/23064 | ISSN: | 1539-1604 | e-ISSN: | 1539-1612 | DOI: | 10.1002/pst.1787 | ISI #: | 000388565400004 | Rights: | (c) 2016 John Wiley & Sons, Ltd. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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van der elst 1.pdf Restricted Access | Published version | 569.88 kB | Adobe PDF | View/Open Request a copy |
Van der Elst et al - Manuscript - revision 3.pdf | Peer-reviewed author version | 379.97 kB | Adobe PDF | View/Open |
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