Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/26085
Title: | Children's screen time alters the expression of saliva extracellular miR-222 and miR-146a. | Authors: | VRIENS, Annette PROVOST, Eline SAENEN, Nelly DE BOEVER, Patrick VRIJENS, Karen De Wever, Oliver PLUSQUIN, Michelle NAWROT, Tim |
Issue Date: | 2018 | Source: | Scientific Reports, 8(1) (Art N° 8209) | Abstract: | An imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and their expression is influenced by a broad range of stimuli. We examined whether screen time, physical activity and BMI are associated with children's salivary extracellular miR-222 and miR-146a expression. In 80 children the extracellular fraction of saliva was obtained by means of differential centrifugation and ultracentrifugation. Expression levels of miR-222 and miR-146a were profiled by qPCR. We studied the association between children's salivary extracellular miRNA expression and screen time, physical activity and BMI using mixed models, while accounting for potential confounders. We found that higher screen time was positively associated with salivary extracellular miR-222 and miR-146a levels. On average, one hour more screen time use per week was associated with a 3.44% higher miR-222 (95% CI: 1.34 to 5.58; p = 0.002) and 1.84% higher miR-146a (95% CI: -0.04 to 3.75; p = 0.055) level in saliva. BMI and physical activity of the child were not significantly associated with either miR-222 or miR-146a. A sedentary behaviour, represented by screen time use in children, is associated with discernible changes in salivary expression of miR-146a and or miR-222. These miRNA targets may emerge attractive candidates to explore the role of these exposures in developmental processes of children's health. | Notes: | Nawrot, TS (reprint author), Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. tim.nawrot@uhasselt.be | Document URI: | http://hdl.handle.net/1942/26085 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-26351-2 | ISI #: | 000433289600025 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © Te Author(s) 2018 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
41598_2018_Article_26351.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
1
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
6
checked on Sep 12, 2024
Page view(s)
82
checked on Sep 6, 2022
Download(s)
132
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.