Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/26315
Title: | Evaluating rodent motor functions: Which tests to choose? | Authors: | Schoenfeld, Lisa-Maria DOOLEY, Dearbhaile Jahanshahi, Ali Temel, Yasin HENDRIX, Sven |
Issue Date: | 2017 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 83, p. 298-312 | Abstract: | Damage to the motor cortex induced by stroke or traumatic brain injury (TBI) can result in chronic motor deficits. For the development and improvement of therapies, animal models which possess symptoms comparable to the clinical population are used. However, the use of experimental animals raises valid ethical and methodological concerns. To decrease discomfort by experimental procedures and to increase the quality of results, non-invasive and sensitive rodent motor tests are needed. A broad variety of rodent motor tests are available to determine deficits after stroke or TBI. The current review describes and evaluates motor tests that fall into three categories: Tests to evaluate fine motor skills and grip strength, tests for gait and inter-limb coordination and neurological deficit scores. In this review, we share our thoughts on standardized data presentation to increase data comparability between studies. We also critically evaluate current methods and provide recommendations for choosing the best behavioral test for a new research line. | Notes: | [Schoenfeld, Lisa-Maria] Heinrich Heine Univ Disseldof, Comparat Psychol, Inst Expt Psychol, Dusseldorf, Germany. [Dooley, Dearbhaile] Univ Coll Dublin, Sch Med, Hlth Sci Ctr, Dublin, Ireland. [Jahanshahi, Ali; Temel, Yasin] Maastricht Univ, Dept Neurosci, Maastricht, Netherlands. [Temel, Yasin] Maastricht Univ, Dept Neurosurg, Med Ctr, Maastricht, Netherlands. [Hendrix, Sven] Hasselt Univ, Dept Morphol, Biomed Res Inst BIOMED, Hasselt, Belgium. | Keywords: | Motor tests; Rodents; Stroke; TBI;motor tests; rodents; stroke; TBI | Document URI: | http://hdl.handle.net/1942/26315 | ISSN: | 0149-7634 | e-ISSN: | 1873-7528 | DOI: | 10.1016/j.neubiorev.2017.10.021 | ISI #: | 000419418700027 | Rights: | © 2017 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
schoenfeld 1.pdf Restricted Access | Published version | 574.09 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
6
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
14
checked on Apr 16, 2024
Page view(s)
64
checked on Sep 7, 2022
Download(s)
56
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.