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|Title:||Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function||Authors:||Cops, Jirka
Verbrugge, Frederik H.
De Moor, Bart
|Issue Date:||2018||Source:||Scientific reports (Nature Publishing Group), 8(1) (Art N° 17757)||Abstract:||Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks. Abdominal venous pressure was significantly higher in the IVCc versus SHAM group (p < 0.0001). Indices of liver and kidney weight, function and morphology, inflammation as well as collagen deposition were significantly increased in the IVCc compared to SHAM group, (p < 0.05). Echocardiographic and hemodynamic parameters were largely unaffected by abdominal venous congestion. In this rat model of isolated abdominal venous congestion, retrogradely conducted glomerular hypertension without a concomitant change in glomerular filtration rate was observed. Adverse short-term hepatic morphological alterations were developed which explain the observed organ function dysfunction. Importantly, cardiac function remained comparable between both groups. This study provides relevant insight in the pathophysiology of abdominal congestion on organ function.||Notes:||Cops, J (reprint author), Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, Diepenbeek, Belgium. email@example.com||Keywords:||COLLAGEN TYPE-IV; HEART-FAILURE; INTRAABDOMINAL PRESSURE; 7S DOMAIN; DYSFUNCTION; INJURY; MECHANISMS; RATS; PATHOPHYSIOLOGY; FIBROGENESIS||Document URI:||http://hdl.handle.net/1942/27503||ISSN:||2045-2322||e-ISSN:||2045-2322||DOI:||10.1038/s41598-018-36189-3||ISI #:||000452673800006||Rights:||Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2019|
|Appears in Collections:||Research publications|
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