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http://hdl.handle.net/1942/28264
Title: | Can we trust self-reported walking distance when determining EDSS scores in patients with multiple sclerosis? The Danish MS hospitals rehabilitation study | Authors: | Guldhammer Skjerbæk, Anders Boesen, Finn Petersen, Thor Vestergaard Rasmussen, Peter Stenager, Egon Nørgaard, Michael FEYS, Peter Kjeldgaard-Jørgensen, Marie Louise Grøndahl Hvid, Lars Dalgas, Ulrik |
Issue Date: | 2018 | Publisher: | SAGE PUBLICATIONS LTD | Source: | Multiple Sclerosis Journal, | Abstract: | Background: In multiple sclerosis (MS), the Expanded Disability Status Scale (EDSS) reflects disease severity. Although parts of the EDSS are dependent on actual walking distance, self-reported statements are often applied. Objectives: The purpose of the present study was, therefore, to compare self-reported walking distance to actual walking distance to outline how this influences EDSS scoring. Methods: MS patients with EDSS 4.0–7.5 (n=273) were included from the Danish MS hospitals rehabilitation study (n=427). All patients subjectively classified their maximal walking distance according to one of seven categories (>500; 300–499; 200–299; 100–199; 20–99; 5–19; 0–4m). Subsequently, actual maximal walking distance was assessed and EDSS was determined from both self-reported walking distance (EDSSself-report) and actual walking distance (EDSSactual). Results: In 145 patients (53%), self-reported walking distance was misclassified when compared to the actual walking distance. Misclassification was more frequent in patients using walking aids (64% vs. 44%, p<0.05) and in patients with primary progressive MS (69%, p<0.05). Misclassification of walking distance corresponded to incorrect EDSS scores (EDSSself-report vs EDSSactual) of ⩾0.5 point in 24%. Conclusion: In MS patients with EDSS 4.0–7.5, 53% misclassified their walking distance yielding incorrect EDSS scores in 24%. Therefore, correct EDSS determination must be based on measurement of actual walking distance. | Keywords: | Outcome measurement; EDSS; Walking; primary progressive MS; multiple sclerosis; Expanded Disability Status Scale | Document URI: | http://hdl.handle.net/1942/28264 | ISSN: | 1352-4585 | e-ISSN: | 1477-0970 | DOI: | 10.1177/1352458518795416 | ISI #: | 000489170300013 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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