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Title: | The Impact of Different Types of Exercise Training on Peripheral BloodBrain‑Derived Neurotrophic Factor Concentrations in Older Adults:A Meta‑Analysis | Authors: | MARINUS, Nastasia HANSEN, Dominique FEYS, Peter MEESEN, Raf TIMMERMANS, Annick SPILDOOREN, Joke |
Issue Date: | 2019 | Publisher: | ADIS INT LTD | Source: | SPORTS MEDICINE, 49 (10), p. 1529-1546 | Abstract: | Background As the prevalence of neurodegenerative diseases (such as dementia) continues to increase due to population aging, it is mandatory to understand the role of exercise for maintaining/improving brain health. Objectives To analyse the impact of aerobic, strength and combined aerobic/strength exercise training on peripheral brain-derived neurotrophic factor (BDNF) concentrations in older adults (minimum age 60 years). Methods This meta-analysis adhered to PRISMA guidelines. Inclusion criteria were: (i) studies with subjects aged ≥ 60 years, (ii) completing a single exercise bout or an exercise programme, with (iii) measurements of blood BDNF in the periphery; (iv) with comparison between (a) an intervention and control group or (b) two intervention groups, or (c) pre- and post-measurements of an exercise intervention without control group. Studies with specific interest in known chronic co-morbidities or brain diseases affecting the peripheral and/or central nervous system, except for dementia, were excluded. Results In general, peripheral blood BDNF concentrations increased significantly after a single aerobic/strength exercise bout (Z = 2.21, P = 0.03) as well as after an exercise programme (Z = 4.72, P < 0.001). However, when comparing the different types of exercise within these programmes, the increase in the peripheral BDNF concentrations was significant after strength training (Z = 2.94, P = 0.003) and combined aerobic/strength training (Z = 3.03, P = 0.002) but not after (low-to-moderate intense) aerobic exercise training (Z = 0.82, P = 0.41). Conclusions Based on current evidence, to increase the peripheral blood BDNF concentrations in older adults, strength training and combined aerobic/strength training is effective. More studies are needed to examine the impact of aerobic exercise training. | Notes: | Marinus, N (reprint author), Hasselt Univ, REVAL Rehabil Res Ctr, Fac Rehabil Sci, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium. Hasselt Univ, BIOMED Biomed Res Ctr, Diepenbeek, Belgium. nastasia.marinus@uhasselt.be | Keywords: | FACTOR BDNF; PHYSICAL-EXERCISE; ELDERLY-WOMEN; RESISTANCE EXERCISE; ALZHEIMER-DISEASE; SKELETAL-MUSCLE; COGNITION; VOLUME; CELLS; IMPROVE | Document URI: | http://hdl.handle.net/1942/28655 | ISSN: | 0112-1642 | e-ISSN: | 1179-2035 | DOI: | 10.1007/s40279-019-01148-z | ISI #: | 000486308500005 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Revised Manuscript - clean copy.pdf | Peer-reviewed author version | 1.32 MB | Adobe PDF | View/Open |
The Impact of Different Types of Exercise Training on Peripheral Blood Brain-Derived Neurotrophic Factor Concentrations in Older Adults_ A Meta-Analysis.pdf Restricted Access | Published version | 2.26 MB | Adobe PDF | View/Open Request a copy |
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