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http://hdl.handle.net/1942/29956
Title: | De novo prediction of the elemental composition of peptides and proteins based on a single mass | Authors: | CLAESEN, Jurgen VALKENBORG, Dirk BURZYKOWSKI, Tomasz |
Issue Date: | 2019 | Publisher: | WILEY | Source: | JOURNAL OF MASS SPECTROMETRY, | Abstract: | Identification of peptides and proteins is a common task in mass spectrometry-based proteomics but often fails to deliver a comprehensive list of identifications. Downstream analysis, quantitative or qualitative, depends on the outcome of this process. Despite continuous improvement of computational methods, a large fraction of the screened peptides and/or proteins remains unidentified. We introduce here pacMASS, a method that de novo predicts the elemental composition of peptides and small proteins based on a single accurate mass, ie, the observed monoisotopic or average mass. This novel approach returns in a fast and memory efficient manner a limited number of elemental compositions per queried peptide or protein. | Notes: | [Claesen, Jurgen; Valkenborg, Dirk; Burzykowski, Tomasz] Hasselt Univ, I BioStat, Hasselt, Belgium. | Keywords: | bioinformatics; identification; massspectrometry; MS1; proteomics;bioinformatics; identification; mass spectrometry; MS1; proteomics | Document URI: | http://hdl.handle.net/1942/29956 | ISSN: | 1076-5174 | e-ISSN: | 1096-9888 | DOI: | 10.1002/jms.4367 | ISI #: | 000489216400001 | Rights: | 2019 John Wiley & Sons,Ltd. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
claesen 1.pdf Restricted Access | Published version | 1.34 MB | Adobe PDF | View/Open Request a copy |
pacMASS_full_resubmitted_JMS_v2.pdf | Peer-reviewed author version | 430.25 kB | Adobe PDF | View/Open |
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