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http://hdl.handle.net/1942/30831
Title: | Cardiovascular Volume Reserve in Patients with Heart Failure and Reduced Ejection Fraction | Authors: | NIJST, Petra MARTENS, Pieter VERBRUGGE, Frederik DUPONT, Matthias Tang, W. H. Wilson MULLENS, Wilfried |
Issue Date: | 2020 | Publisher: | SPRINGER | Source: | JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 13(4), p. 519-527 | Abstract: | This study aimed to investigate the relationship between intravascular volume and intracardiac filling pressures in stable HF patients with reduced ejection fraction (HFrEF). A total of 40 HFrEF patients (LVEF 36 +/- 10%) (10 subjects with a pulmonary artery catheter) underwent intravascular volume expansion with 1 L hydroxyl-ethyl-starch over 3 h with coinciding intravascular volume measurements (technetium (99 tc)-labeled red blood cell technique). Intravascular blood volume increased from 5.0 +/- 1.0 L to 5.7 +/- 1.0 L (p < 0.0001). No change in clinical status, echocardiographic indices, or cardiac filling pressures was noticed. Invasively measured right atrial pressure and pulmonary arterial wedge pressure increased significantly immediately after start of infusion (4 +/- 2 mmHg to 8 +/- 4 mmHg; p = 0.01 and 10 +/- 3 mmHg to 15 +/- 6 mmHg; p = 0.01, respectively), decreased afterwards, and remained stable for 3 h (6 +/- 2 mmHg and 14 +/- 4 mmHg, respectively). The accuracy of cardiac filling pressure estimates to predict intravascular volume expansion was low (all AUC < 0.65). | Notes: | Nijst, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium.; Nijst, P (reprint author), Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. petranijst@gmail.com |
Other: | Nijst, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium, Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. petranijst@gmail.com | Keywords: | Central venous pressure;Echocardiography;Plasma volume;Pulmonary wedge pressure;Systolic heart failure;Congestion | Document URI: | http://hdl.handle.net/1942/30831 | ISSN: | 1937-5387 | e-ISSN: | 1937-5395 | DOI: | 10.1007/s12265-020-09973-8 | ISI #: | WOS:000515917200001 | Rights: | Springer Science+Business Media, LLC, part of Springer Nature 2020 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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