Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/32012
Title: Accelerated Polypeptide Synthesis via N-CarboxyanhydrideRing Opening Polymerization in Continuous Flow
Authors: VRIJSEN, Jeroen 
Rasines Mazo, Alicia
JUNKERS, Tanja 
Qiao, Greg Guanghua
Issue Date: 2020
Publisher: WILEY-V C H VERLAG GMBH
Source: Macromolecular rapid communications, 41 (18), (Art N° 2000071)
Abstract: In nature, polypeptide-based materials are ubiquitous, yet their synthetic production is hampered by high cost, limited scalability, and often stringent reaction conditions. Herein an elegant approach is presented forN-carboxyanhydride ring opening polymerization (NCA ROP) ofN epsilon-benzyloxycarbonyl-l-lysine (ZLL) and gamma-benzyl-l-glutamate (BLG) NCA in continuous flow. The polymerization is initiated by primary amine initiators usingN,N-dimethylformamide (DMF) as solvent. Carrying out the reaction in a silicon microflow reactor speeds up the rate of ROP (92% conversion in 40 min in flow as opposed to 6 h in batch) due to highly efficient permeation of CO(2)through the reactor tubing. The polymerization strategy provides a facile, scale-up friendly alternative to traditional batch mode polymerization and has the capability of streamlining NCA ROP.
Notes: Qiao, GG (corresponding author), Univ Melbourne, Polymer Sci Grp, Dept Chem Engn, Parkville, Vic 3010, Australia.; Junkers, T (corresponding author), Hasselt Univ, Organ & Bio Polymer Chem, Inst Mat Res, Agoralaan, B-3590 Diepenbeek, Belgium.; Junkers, T (corresponding author), Monash Univ, Polymer React Design Grp, Sch Chem, Clayton, Vic 3800, Australia.
tanja.junkers@monash.edu; gregghq@unimelb.edu.au
Other: Qiao, GG (corresponding author), Univ Melbourne, Polymer Sci Grp, Dept Chem Engn, Parkville, Vic 3010, Australia. Junkers, T (corresponding author), Hasselt Univ, Organ & Bio Polymer Chem, Inst Mat Res, Agoralaan, B-3590 Diepenbeek, Belgium; Monash Univ, Polymer React Design Grp, Sch Chem, Clayton, Vic 3800, Australia. tanja.junkers@monash.edu; gregghq@unimelb.edu.au
Keywords: continuous flow chemistry;flow polymerization;N-carboxyanhydride ring opening polymerization
Document URI: http://hdl.handle.net/1942/32012
ISSN: 1022-1336
e-ISSN: 1521-3927
DOI: 10.1002/marc.202000071
ISI #: WOS:000550449800001
Rights: 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Category: A1
Type: Journal Contribution
Validations: ecoom 2021
Appears in Collections:Research publications

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